Synthetic method of efficient high-stability catalyst for aqueous phase click reaction

A high-stability, click-reaction technology, applied in chemical instruments and methods, physical/chemical process catalysts, organic compounds/hydrides/coordination complex catalysts, etc., can solve problems affecting reaction activity and achieve high catalytic activity , less dosage, high stability effect
CN104084237AInactive Publication Date: 2014-10-08SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2014-10-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthetic method of an efficient high-stability catalyst for an aqueous phase click reaction. The synthetic method comprises the following steps of synthesizing a water-soluble multi-dentate triazole ligand by virtue of a multi-step organic reaction, and coordinating the water-soluble multi-dentate triazole ligand with copper salt to form a cuprous catalyst. Due to the special and stable structure, the catalyst has the characteristics that the water solubility is good, the catalytic efficiency is high, and the catalyst can stably exist in air, can be used in an acid or alkali environment and can effectively resist the interference of primary amine or halide ions; the efficient high-stability catalyst has bright prospects in various fields spanning over a plurality of subjects such as designed synthesis and modification of water-soluble polymers, combinatorial chemistry, surface modification, medicinal chemistry and molecular biology.
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Description

technical field

[0001] The present invention relates to a synthesis method of a catalyst, in particular to a synthesis method of a click reaction catalyst, in particular to a highly stable catalyst suitable for the click reaction of Cu(I) catalyzed azide and terminal alkyne in the water phase resolve resolution. Background technique

[0002] The Cu(I)-catalyzed click reaction between azide and terminal alkyne is one of the most famous and representative click reactions, which belongs to a kind of 1,3 dipolar cycloaddition reaction. Because of its mild reaction conditions, less reaction interference, high reaction selectivity and high reaction efficiency, it is widely used in almost every branch of chemistry. Its most important applications focus on the design and modification of polymers, surface modification, molecular labeling and pharmaceutical combinatorial chemistry. The use of this type of reaction catalyst is divided into two categories. The first category was first...

Claims

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