Micronized glibenclamide and composition thereof

A technology of micronization and composition, applied in the field of medicine, can solve the problems of high energy, shortened time to peak blood concentration of glibenclamide, and life-threatening problems
CN104098489AInactive Publication Date: 2014-10-15SHENYANG PHARMA UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2014-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to composition containing micronized glibenclamide. Particle sizes d0.5 of the micronized glibenclamide are in a range of 0.2 mu m-5 mu m, and the micronized glibenclamide is combined with a carrier to prepare a preparation with the proper dissolution rate. The invention further relates to a method for preparing the micronized glibenclamide solid preparation. By the aid of the method, the solubility of the glibenclamide is improved, the bioavailability is improved, and clinical effects of the pharmaceutical preparation are increased.
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Description

technical field

[0001] The invention relates to a micronized glibenclamide and its composition, in particular to a solid preparation made of micronized glibenclamide and pharmaceutically acceptable additives made by ultrafine pulverization technology, belonging to field of medical technology. Background technique

[0002] Glibenclamide (Glibenclamide) is a second-generation sulfonylurea drug, and its oral preparation has the advantages of fast absorption and high protein binding rate (95%). It is currently the first-line drug for the treatment of type Ⅱ diabetes, and its effect is stronger than that of tolbutamide 100-200 times, so the dosage is significantly reduced. This product can stimulate islet β cells to secrete insulin and lower blood sugar. The prerequisite is that the pancreatic β cells still have a certain function of synthesizing and secreting insulin; this product can also inhibit the decomposition of liver glycogen by increasing the level of portal vein insuli...

Claims

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