Colloidal bismuth pectin capsule and preparation process thereof

A technology of colloidal bismuth pectin and preparation process is applied in the directions of capsule delivery, medical preparations without active ingredients, medical preparations containing active ingredients, etc. To achieve the effect of simple preparation process, strong adsorption, easy to industrialize large-scale production

Active Publication Date: 2014-10-29
桂林华信制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of this invention includes the preparation of liposome precursors, microwave reaction to form nano-liquid, spray drying to form nanoparticles, and preparation of granules. The process is complicated and the production cost is high.
Organic solvents such as tetrahydrofuran are used in the preparation process, which is not conducive to labor protection
At the same time,

Method used

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  • Colloidal bismuth pectin capsule and preparation process thereof
  • Colloidal bismuth pectin capsule and preparation process thereof
  • Colloidal bismuth pectin capsule and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025]

[0026] Preparation Process:

[0027] (1) Add colloidal pectin bismuth and diatomaceous earth to a ball mill and pulverize to obtain the drug-containing adsorbate, and control the average particle size of the drug-containing adsorbate to be less than 30 microns;

[0028] (2) The drug-containing adsorbate obtained in step (1) is uniformly mixed with crospovidone and sodium stearate fumarate, and the capsule shell is filled.

Example Embodiment

[0029] Example 2

[0030]

[0031]

[0032] Preparation Process:

[0033] (1) Add colloidal pectin bismuth and diatomaceous earth to a ball mill and pulverize to obtain the drug-containing adsorbate, and control the average particle size of the drug-containing adsorbate to be less than 30 microns;

[0034] (2) The drug-containing adsorbate obtained in step (1) is uniformly mixed with croscarmellose sodium and hydrogenated vegetable oil, and the capsule shell is filled.

Example Embodiment

[0035] Example 3

[0036]

[0037] Preparation Process:

[0038] (1) Add colloidal pectin bismuth and diatomaceous earth to a ball mill and pulverize to obtain the drug-containing adsorbate, and control the average particle size of the drug-containing adsorbate to be less than 30 microns;

[0039] (2) The drug-containing adsorbate obtained in step (1) is uniformly mixed with sodium carboxymethyl starch and magnesium stearate, and the capsule shell is filled.

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Abstract

The invention discloses a colloidal bismuth pectin capsule and a preparation process thereof. The capsule is formed by filling content into a capsule shell, and the content contains kieselguhr of adsorbing colloidal bismuth pectin. By adopting the preparation process, the colloidal bismuth pectin and the kieselguhr are added to a ball grinder so as to be crushed, and the colloidal bismuth pectin can be evenly adsorbed on the surface of the kieselguhr or into holes after the colloidal bismuth pectin and the kieselguhr are crushed, so that the medicine is prevented from easily agglomerating in water.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a capsule containing colloidal bismuth pectin and a preparation process thereof. Background technique [0002] Colloidal bismuth pectin is a new type of colloidal bismuth preparation, which is a salt formed of biomacromolecule pectinic acid (D-polygalacturonic acid) and metal bismuth ions and potassium ions. The mechanism of action of colloidal bismuth pectin is that this product has strong colloidal properties. Colloidal bismuth pectin uses biomacromolecule pectinic acid to replace the small molecular acid radicals in the existing bismuth preparations, such as carbonate, nitrate and citrate. etc., thereby changing the colloidal characteristics of colloidal bismuth, making it form a high-viscosity sol in acidic medium, and forming a firm protective film on the gastric mucosa. Enhance the barrier function of gastric mucosa In vitro experiments have...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/732A61K47/04A61P31/04A61P1/04
Inventor 严白双
Owner 桂林华信制药有限公司
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