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Method for preparing enzyme-extracted traditional Chinese medicine granules for livestock and poultry

A technology of traditional Chinese medicine granules, livestock and poultry, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antipyretics, etc. High content of ingredients, obvious curative effect, antibacterial and anti-inflammatory effect

Inactive Publication Date: 2014-11-19
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation method of Banqing granules is to extract the traditional Chinese medicine by decocting and concentrating, and then add auxiliary materials. However, the extraction rate of this method is low, and some active ingredients are locked in the cell wall and it is difficult to extract. The traditional detection method can only It is difficult to evaluate the strength of its medicinal effect by thin-layer chromatography to identify the existence of its active ingredients. Therefore, although the theoretical effect of Banqing Granules is good, it is difficult to fully exert the medicinal effect due to the limitation of the extraction method.

Method used

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  • Method for preparing enzyme-extracted traditional Chinese medicine granules for livestock and poultry
  • Method for preparing enzyme-extracted traditional Chinese medicine granules for livestock and poultry

Examples

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Effect test

Embodiment 1

[0010] A preparation method of enzyme-extracted traditional Chinese medicine granules used by livestock and poultry, comprising the following steps: (1) Weighing 30g of Folium Isatidis, 70g of Radix Isatidis, 40g of anhydrous glucose and 40g of maltodextrin, mixing Folium Isatidis and Radix Isatidis, and pulverizing , through a 20-mesh sieve, adding water 8 times the total weight of Folium Folium Isatidis and Radix Radix to infiltrate for 4 hours; (2) adding cellulase and pectinase, the amount of cellulase added is the total amount of the product obtained in step (1). 1% of the weight, the addition of pectinase is 1.5% of the total weight of the resultant in step (1), and stir evenly; (3) react the obtained mixture for 4 hours at 40°C and pH=3, and the stirring speed is 40 rev / min, then decoct and extract the reaction product twice with water, combine and concentrate the extract to 0.4g / mL crude drug; (4) add anhydrous glucose and maltodextrin to make soft material, pass throug...

Embodiment 2

[0012] A preparation method of enzyme-extracted traditional Chinese medicine granules used by livestock and poultry, comprising the following steps: (1) Weighing 40g of Folium Isatidis, 60g of Radix Isatidis, 60g of soluble starch, 10g of lactose and 10g of sucrose, mixing Folium Isatidis and Radix Isatidis, and pulverizing , passed through a 20-mesh sieve, and soaked in water 9 times the total weight of Folium Isatidis and Radix Radix for 6 hours; (2) Add cellulase and xylanase, the amount of cellulase added is the result of step (1) 0.5% of the total weight, the addition of xylanase is 1% of the total weight of the product obtained in step (1), and stir evenly; (3) react the obtained mixture at 50°C and pH=4 for 6 hours, stir The speed is 60 rpm, and then the reaction product is decocted and extracted 3 times, and the extract is combined and concentrated to 0.8g / mL crude drug; (4) Add soluble starch, lactose and sucrose to make a soft material, and pass it through a granulato...

Embodiment 3

[0014] A preparation method for enzyme-extracted traditional Chinese medicine granules used by livestock and poultry, comprising the following steps: (1) weighing 60 g of Folium Isatidis, 40 g of Radix Radix, 40 g of maltodextrin, 20 g of mannitol and 20 g of anhydrous glucose, and mixing Folium Folium and Mix Radix Isatidis, crush it, pass through a 40-mesh sieve, add water 10 times the total weight of Radix Folium Isatidis and Radix Isatidis to infiltrate for 2 hours; (2) add cellulase, pectinase and xylanase, and add cellulase Amount is 1.5% of the total weight of the product of step (1), the addition of pectinase is 2% of the total weight of the product of step (1), and the addition of xylanase is 2% of the total weight of the product of step (1). 1.5%, stir evenly in the reactor; (3) React the obtained mixture at 30°C and pH=6 for 7 hours at a stirring speed of 80 rpm, then decoct and extract the reaction product 4 times with water. The extracts are combined and concentra...

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Abstract

The invention relates to a method for preparing enzyme-extracted traditional Chinese medicine granules for livestock and poultry. The method comprises the following steps: mixing indigowoad leaf with isatis root in proportion, smashing the mixture into traditional Chinese medicine powder with the granularity of 20-40 meshes, adding water with the weight 8-10 times the total weight of the traditional Chinese medicines and soaking for 2-6 hours; adding at least one of cellulase, pectinase and xylanase and uniformly stirring, wherein the adding amount of the enzyme accounts for 0.5-5wt% of the reaction system; reacting the obtained mixture for 4-8 hours under the conditions that the temperature is 30-50 DEG C and the pH is 3-7, wherein the stirring speed is set at 40-100 revolutions per minute in the reaction process; adding water and decocting the reaction product, extracting, combining the extracting solutions and concentrating into 0.4-1.5g / mL crude drug; and adding at least one of water soluble starch, anhydrous glucose, mannitol, maltodextrin, lactose and saccharose to prepare a soft material, granulating through a granulator, drying and screening to obtain the finished granules.

Description

technical field [0001] The invention belongs to the technical field of animal and poultry medicines, and relates to a preparation method of enzyme-extracted traditional Chinese medicine granules used by livestock and poultry. Background technique [0002] In recent years, enzyme engineering has been widely used in food processing, and there are more and more types. Cellulase is a kind of enzyme, which plays a biocatalytic role in decomposing cellulose. Cellulase exists widely in organisms in nature, and bacteria, fungi, and animals can all produce cellulase. The cellulase generally used for production comes from fungi, typically Trichoderma, Aspergillus and Penicillium. Cellulase can improve the utilization rate of raw materials. Pectinase refers to the general term of various enzymes that commonly exist in bacteria, fungi and plants to decompose gum substances. Root Chinese medicinal materials often contain many viscous substances, usually including protein, Starch, tanni...

Claims

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Application Information

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IPC IPC(8): A61K36/195A61K36/704A61K36/315A61K36/855A61K9/16A61P29/00A61P31/04A61P11/00
Inventor 王选年张艳芳张遂平李鹏郭芳茹苑青艳吴胜耀杜雪峰郭菊王菊萍杨果张海涛
Owner 河南亚卫动物药业有限公司