A method for constructing micro-nano pores on the surface of composite ceramic bone scaffold

A technology of composite ceramics and bone scaffolds, applied in medical science, prostheses, etc., can solve problems such as high brittleness, difficult to control degradation rate, and insufficient bending strength

Inactive Publication Date: 2016-01-06
CENT SOUTH UNIV
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Problems solved by technology

[0005] However, this kind of material has the disadvantages of high brittleness, insufficient bending strength, and difficult to control the degradation rate, while composite ceramics have better mechanical properties and adjustable degradation rate than single materials, so at present, more and more composite ceramic bone scaffolds are used. (such as HAP / TCP) to repair bone defects

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  • A method for constructing micro-nano pores on the surface of composite ceramic bone scaffold
  • A method for constructing micro-nano pores on the surface of composite ceramic bone scaffold
  • A method for constructing micro-nano pores on the surface of composite ceramic bone scaffold

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Embodiment Construction

[0023] The specific implementation manner of the present invention will be further described below in conjunction with an embodiment, but the content of the present invention is not limited thereto.

[0024] 1) Nano-HAP powder and β-TCP powder are used as raw materials. HAP powder is purchased from Nanjing Epurui Nano Material Co., Ltd. and prepared by sol-gel method. It is long needle-shaped, about 20nm wide, about 150nm long, and the average particle Diameter 40nm. β-TCP powder was provided by Kunshan Huaqiao Technology New Material Co., Ltd., China, prepared by precipitation method, and Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 As a raw material, it is prepared by calcining at 700-800°C and holding for 3-5 hours. The powder is white amorphous powder; the average particle size is 200nm, the melting point is 1670°C, and the bulk density is 0.75g / cm 3 , the Ca / P ratio is 1.50. The HAP / β-TCP composite powders with different ratios were obtained after grinding for 60 min by mechani...

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Abstract

The invention provides a construction method aimed at an HAP / TCP composite ceramic bone scaffold used for repairing bone defect at present. The characteristic is utilized that the degradation velocities of hydroxylapatite and calcium phosphate are different, namely the chemical reaction velocity of beta-TCP and phosphoric acid is far faster than the chemical reaction velocity of HAP and phosphoric acid. When corrosion is carried out by utilization of a phosphoric acid, the beta-TCP particles on the composite ceramic bone scaffold surface are dissolved in the phosphoric acid, and micro-pores are formed; HAP particles are corroded slightly and nano pores are formed on the crystal grain surface. The surface micro-nano pores which are suitable for cell adhesion growth are formed finally, and the formed micro-nano pores have a certain regularity.

Description

Technical field [0001] The invention relates to a method for constructing micro-nano pores on the surface of a hydroxyapatite / tricalcium phosphate composite ceramic bone scaffold, in particular to a bone preparation method for laser selective sintering of nano-hydroxyapatite and tricalcium phosphate mixed powder. The scaffold utilizes the inconsistency in the degradation rates of hydroxyapatite and tricalcium phosphate, and uses phosphoric acid solution to selectively corrode bone scaffolds to obtain micro-nano pores on the surface. Background technique [0002] As people's average life expectancy continues to increase and the population ages, bone defects caused by orthopedic diseases are on the rise. There are more than 2.2 million bone defect surgery patients worldwide every year. In recent years, with the gradual maturity of biomanufacturing technology, it has become possible to use artificial bone scaffolds to repair bone defects. However, it usually takes 1-3 months o...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/10
Inventor 帅词俊彭淑平李鹏建庄静宇
Owner CENT SOUTH UNIV
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