Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof

A technology for osteoporosis and composition, which is applied in the field of medicine, can solve the problems of increasing bone density and bone weight coefficient, poor symptom control, increasing blood phosphorus and blood calcium, etc., and achieves the effect of raising blood calcium and treating The effect of definite, blood phosphorus and serum alkaline phosphatase reduction

Inactive Publication Date: 2014-11-26
王鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the technical deficiencies in the prior art that the symptoms of osteoporosis after chemotherapy for malignant tumors are not well controlled, the present invention provides a pharmaceutical composition for treating osteoporosis after chemotherapy for malignant tumors, which contains alendronate Pomalidomide and pomalidomide are the active ingredients of the medicine. When the medicine composition is used for the treatment of osteoporosis after chemotherapy for malignant tumors, the symptoms are well controlled, and it can improve bone density and bone weight coefficient as well as blood phosphate levels. It has a significant synergistic effect in terms of calcium content, and is suitable for the treatment of osteoporosis caused by clinical tumor chemotherapy

Method used

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  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof
  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof
  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of alendronate pomalidomide compound tablet

[0021]

[0022] Preparation process: first put alendronic acid and cyclodextrin into a mortar, grind and mix uniformly, sequentially add sodium carboxymethyl starch, compressible starch and mix well, finally add pomalidomide and mix well, use 5% PVP The anhydrous ethanol solution is used as a binder for granulation, dried at 40°C, granulated, mixed with magnesium stearate, and compressed into tablets.

Embodiment 2

[0023] Example 2 Preparation of alendronate pomalidomide compound tablet

[0024]

[0025] Preparation process: first put alendronic acid and cyclodextrin into a mortar, grind and mix uniformly, sequentially add sodium carboxymethyl starch, compressible starch and mix well, finally add pomalidomide and mix well, use 5% PVP The anhydrous ethanol solution is used as a binder for granulation, dried at 40°C, granulated, mixed with magnesium stearate, and compressed into tablets.

Embodiment 3

[0026] Example 3 Preparation of alendronate pomalidomide compound tablet

[0027]

[0028] Preparation process: first put alendronic acid and β-cyclodextrin in a mortar, grind and mix uniformly, add sodium carboxymethyl starch, microcrystalline cellulose, and micro-powdered silica gel in sequence, and finally add pomalidomide and mix well , The powder is directly pressed into tablets, ready to be obtained

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating post-malignant tumor-chemotherapeutic osteoporosis and use thereof and belongs to the field of medicines. In order to overcome the technical defect that the medicine for treating post-malignant tumor-chemotherapeutic osteoporosis in the prior art is poor to control symptoms, the invention provides a pharmaceutical composition containing alendronic acid and pomalidomide. The pharmaceutical composition used for treating post-malignant tumor-chemotherapeutic osteoporosis is good to control symptoms and has a remarkable effect in increasing bone mineral density and bone weight coefficient as well as increasing content of serum inorganic phosphorus and blood calcium, so that the pharmaceutical composition is suitable for clinically treating tumor chemotherapy induced osteoporosis.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition for treating osteoporosis after chemotherapy and its use, in particular to a pharmaceutical composition containing alendronic acid and pomalidomide and its use for treating malignant tumors after chemotherapy The medical use of osteoporosis belongs to the field of medicine. Background technique [0002] Malignant tumors are often called cancers, which are common and frequently-occurring diseases that seriously threaten human health. Currently, the three main methods of treating malignant tumors include chemotherapy (chemotherapy for short), surgery and radiation therapy. The application of traditional cytotoxic anti-tumor drugs or anti-cancer drugs for chemotherapy still occupies an extremely important position in the comprehensive treatment of tumors. Some malignant tumors such as choriocarcinoma and malignant lymphoma may be cured by chemotherapy. However, the treatment of solid tumors, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61P19/10A61K31/4439
Inventor 王深涧
Owner 王鹏
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