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Non-invasive skin free-cholesterol detection device for evaluating atherosclerosis risk

A technology for atherosclerosis and risk assessment, applied in applications, biological testing, material inspection, etc., can solve problems such as large color differences, skin surface shape changes, complex procedures, etc., to achieve consistent contact pressure and reduce measurement errors , to avoid the effect of measurement error

Active Publication Date: 2014-12-03
ANHUI YIKANGDA PHOTOELECTRIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This analysis method is complicated, and more importantly, the reagents used are corrosive and irritating to human skin, and are not suitable for long-term and self-testing by the subjects.
[0008] Chinese patent CN1961078 mentions that the cholesterol sample of the outer stratum corneum of the skin is sticked with adhesive tape to realize cholesterol detection, but the whole detection process requires multiple experiments, the procedure is complicated, and it takes a long time. Moreover, it is difficult to ensure the repeatability of the experimental process. , leading to differences in the measured cholesterol levels
This method is simple and fast, but during the detection process, the different contact pressure between the device and the skin will cause changes in the shape of the skin surface, thereby reducing the repeatability of color measurement, and the skin is the substrate of the test agent, for different subjects , the color difference is large, which brings great interference to the measurement of reagent color
In addition, the difference in ambient temperature will cause the activity of the enzyme in the detection reagent to be different, resulting in measurement errors

Method used

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  • Non-invasive skin free-cholesterol detection device for evaluating atherosclerosis risk
  • Non-invasive skin free-cholesterol detection device for evaluating atherosclerosis risk
  • Non-invasive skin free-cholesterol detection device for evaluating atherosclerosis risk

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Cholesterol-specific conjugates, enzymes, and cross-linking agents in the detection reagent are polymers of digitonin, horseradish peroxidase, and maleic anhydride-N-vinylpyrrolidone, respectively, and the main component of the indicator is 3,3' ,5,5'-Tetramethylbenzidine. First, clean the skin of the palm of the subject, and after the skin is dry, drop the detection reagent onto the part of the palm to be tested. After approximately 1 minute of incubation, blot the test area dry to remove detection reagent that is not bound to free cholesterol. Then, drop 3,3',5,5'-tetramethylbenzidine in the test area to react with the horseradish peroxidase in the detection reagent, and the degree of reaction is related to the combined digitonin and cholesterol content in the skin Proportional. After another 2 minutes, the diffuse reflectance spectrum of the reaction reagent is measured using a detection device.

[0039] The detection device is composed of a light source part, a t...

Embodiment 2

[0044] In this embodiment, a lens group is used instead of an optical fiber when constructing the transmitting part and the receiving part. The light source is a white LED, and the light emitted by the LED passes through the emitting part composed of a collimating lens group and a filter, and then irradiates the selected area of ​​the skin coated with the reagent, and the reflected light in this area passes through a receiving part composed of a filter and a lens. After that, it is received by the light detection component, where the light detection component is a micro spectrometer. By optimizing the design of the focal length, relative position, and relative angle of the transmitting part and the receiving part, the receiving part can only receive the light beam reflected by the reaction reagent, and avoid the influence of the light beam reflected by the subject's skin on the measurement result. The analysis and processing system analyzes and processes the spectral informati...

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Abstract

The invention relates to a non-invasive skin free-cholesterol detection device for evaluating the atherosclerosis risk. A palm part of a tester is coated with a specific reagent, the relative content of free cholesterol on the skin of the tester can be acquired by measuring the variation situation of a reaction reagent reflection spectrum by utilizing an optical method, and then the risk for a subject suffering the atherosclerosis disease can be further evaluated.

Description

technical field [0001] The invention relates to a non-invasive detection device for skin free cholesterol for risk assessment of atherosclerosis, and is especially suitable for early detection of atherosclerosis. Background technique [0002] With the development of society and economy and the change of people's lifestyle, atherosclerosis and various cardiovascular and cerebrovascular diseases caused by it have become a major killer of human health. In developed countries, the morbidity and fatality rate of this disease account for the first among all diseases, while in developing countries including my country, the morbidity and incidence of this disease also show an increasing trend year by year. Most patients with early atherosclerosis have no obvious symptoms, some patients fail to see a doctor in time even if they have symptoms, and some patients have sudden death as the first manifestation, so prevention is particularly important. A large amount of epidemiological and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/92G06F19/00A61B5/00
CPCA61B5/0059G01N21/27
Inventor 刘勇董美丽朱灵邓国庆王贻坤
Owner ANHUI YIKANGDA PHOTOELECTRIC TECH CO LTD
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