Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biodegradable material and method for producing biodegradable material

A biodegradable compound technology, applied in tissue regeneration, bandages, surgery, etc., can solve problems such as deformation of polymer particles, and achieve the effects of improving softness, shear strength, and shape recovery rate

Inactive Publication Date: 2014-12-03
TORAY IND INC
View PDF17 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] However, improved techniques such as blending of various polymers (Patent Document 7) and use of chemically crosslinked polymer particles (Patent Document 8) and surface coating of polymer particles (Patent Document 9) are not available. In other words, improvements have been confirmed in terms of controlling the flexibility of polymer particles and improving catheter penetrability, but sufficient improvement has not been confirmed for the problem that polymer particles deform and do not return to their original shape. In order to obtain a suitable The embolization effect of blood vessels etc. needs further improvement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable material and method for producing biodegradable material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0217] 10.0 g of branched chain polymer a1, 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) and hydroxycarboxylic acid a2, namely 22.0 g of lactide (PURASORB L; manufactured by PURAC BIOMATERIALS) were extracted. into an eggplant-shaped bottle. These were melt-mixed at 120° C. under an argon atmosphere, and 0.94 mL of tin (II) octoate toluene solution was added as a catalyst (tin (II) octoate (manufactured by Sigma-Aldrich Co.,) was dissolved in toluene (Wako Pure Chemical Industries, Ltd. Kogyo Co., Ltd., adjusted to a concentration of 0.16 g / mL), and a copolymerization reaction was performed under normal pressure for 20 hours to obtain an unpurified multi-component compound A1.

[0218] The obtained unrefined multi-component compound A1 was added dropwise to 100 mL of diethyl ether, and after the precipitate and liquid components separated from diethyl ether were collected, they were further washed with 50 mL of diethyl ether for 3...

Embodiment 2）

[0227] Respectively change the consumption of solution 1 to 0.570mL, change the consumption of solution 2 to 0.430mL, change the consumption of DMAP solution to 0.022mL, change the consumption of EDC to 0.038mL, except that, carry out the same as Example 1 Operation, thereby obtaining biodegradable membrane 2 and acetonitrile-containing membrane 2.

[0228] These biodegradable film 2 and acetonitrile-containing film 2 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0229] As shown in Table 1, the biodegradable film 2 has a large compressive load and a high recovery rate. In addition, the complex elastic modulus of the acetonitrile-containing membrane 2 is large, and the gelation time is also fast.

Embodiment 3）

[0231] Change the consumption of solution 1 to 0.399mL, change the consumption of solution 2 to 0.601mL, change the consumption of DMAP solution to 0.030mL, and change the consumption of EDC to 0.053mL, except that, carry out the same as Example 1 Operation, thereby obtaining biodegradable membrane 3 and acetonitrile-containing membrane 3.

[0232] These biodegradable films 3 and acetonitrile-containing films 3 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0233] As shown in Table 1, the biodegradable film 3 has a large compressive load and a high recovery rate. In addition, the complex elastic modulus of the acetonitrile-containing membrane 3 is large, and the gelation time is also fast.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The objective of the present invention is to provide a biodegradable material that has improved flexibility and increased percentage of shape recovery after the material has been deformed. The present invention provides a biodegradable material resulting from a polyvalent compound (A) having at least three functional groups (X) such as hydroxyl groups and a polyvalent compound (B) having at least three functional groups (Y) such as carboxyl groups being chemically crosslinked by means of a condensation reaction, and when the number of functional groups (X) that are not condensed to functional groups (Y) is x, the number of functional groups (Y) that are not condensed to functional groups (X) is y, the number of chemical crosslinks is z, the weight average molecular weight of polyvalent compound (A) is MA, and the weight average molecular weight of polyvalent compound (B) is MB, when MA >= MB, the value of (y+z) / (x+z) is 1.2-4.0, and when MA < MB, the value of (x+z) / (y+z) is 1.2-4.0.

Description

technical field [0001] The present invention relates to a biodegradable material and a method for producing the biodegradable material. Background technique [0002] Poly(lactic acid / glycolic acid) copolymers are used as polymer particles for embolization of blood vessels in order to stop bleeding during incision of the affected part, block the nutrient supply to the tumor, maintain the concentration of anticancer agents in the tumor, etc. (Patent Document 1); block copolymers of polyethylene glycol and polylactic acid (Patent Documents 2 to 5); or multi-block copolymers obtained by copolymerizing lactic acid, polyethylene glycol, and polycarboxylic acids (Patent Document 6 ). [0003] Such polymer particles for embolization of blood vessels etc. use spherical particles in order to embolize blood vessels etc. without gaps, but since they are delivered to target sites such as blood vessels through microcatheters with small diameters, there are the following problems : Block...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/00A61L15/64A61L17/00C08G63/06C08L101/16
CPCA61L24/0042C08L101/16A61L15/64A61L31/148C08G63/08C08G63/668C08L67/02A61L2430/36C08L67/025C08L67/04A61L15/26A61L24/046
Inventor 藤田雅规中西惠棚桥一裕
Owner TORAY IND INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com