Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of synthetic method of 2-chloro-5-iodobenzoic acid

A technology of iodobenzoic acid and synthesis method, which is applied in chemical instruments and methods, preparation of carboxylate, preparation of oxygenated compounds, etc., can solve the problems of complex synthesis method, troublesome operation, low yield and the like, and achieves simple process and high production efficiency. Process safety and easy operation

Inactive Publication Date: 2015-10-21
姜树林
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This synthetic method has disadvantages such as low yield, complex synthetic method, and cumbersome operation, which needs to be improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of synthetic method of 2-chloro-5-iodobenzoic acid
  • A kind of synthetic method of 2-chloro-5-iodobenzoic acid
  • A kind of synthetic method of 2-chloro-5-iodobenzoic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of synthetic method of 2-chloro-5-iodobenzoic acid:

[0028] 1. Iodine, substitution

[0029] Determine the mass ratio of raw materials and reagents as methyl anthranilate: potassium iodate: iodide: dichloromethane: water: sodium sulfite: ethanol: sodium methoxide methanol solution: acetic acid: water = 1: 0.4~0.5: 0.8~ 1:2~5:1.5~3:0.008~0.01:3~5:0.25~0.4:0.02~0.05:0.08~0.1

[0030] Add 588ml of water and 242.4g of potassium iodide into a 2L three-necked flask and stir to dissolve. Add 139.1g of potassium iodate, stir to dissolve, add 300g of methyl anthranilate, then add 99.3ml of dichloromethane, add 191.8g of glacial acetic acid dropwise through the dropping funnel, finish adding in about 1.5 hours, and the temperature rises to 50 ℃, stirred for 30 minutes after the addition, the temperature rose to 55 ℃ and kept for 2 hours, cooled to 35 ℃, added 397.4ml of dichloromethane, stirred for 15 minutes, added 2.8g of solid sodium sulfite in batches, cooled to 25 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A synthetic method of 2-chloro-5-iodobenzoic acid is disclosed. The target product is obtained by subjecting methyl 2-aminobenzoate to iodination, substitution, a Sandmeyer reaction and hydrolysis under alkaline conditions. The method is characterized by modification or optimization of process steps and parameters based on traditional iodination, substitution, the Sandmeyer reaction and hydrolysis. The method is simple in process, easy in operation, safe in production process, free of pollution, and high in yield of each step. The purity of the product is 95-98%. The total yield of the product is 64-70%.

Description

technical field [0001] The invention relates to a method for synthesizing benzoic acid, in particular to a method for synthesizing 2-chloro-5-iodobenzoic acid, belonging to the field of chemical synthesis. Background technique [0002] 2-Chloro-5-iodobenzoic acid is an aromatic functional monomer with two different halogens and one carboxyl group. It can use the activity difference of each group to react with different groups to synthesize compounds substituted by various functional groups. It is widely used in medicine, metal organic chemistry, etc., and is mainly used in the synthesis of the latest hypoglycemic drug dapagliflozin (BMS-512148). About its synthesis method, there are few literature reports at present. [0003] At present, it is disclosed that a cheap methyl anthranilate is used as a starting material, and iodine is carried out with iodine to obtain methyl 2-amino-5 iodobenzoate, and then the classic Sandmeyer reaction is carried out, and after chlorination ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C63/70C07C27/02C07C229/56C07C227/18C07C227/16C07C69/767C07C67/307
CPCC07C51/09C07C67/307C07C227/16C07C227/18C07C69/76C07C63/70C07C229/56
Inventor 王德峰俞健钧石飞
Owner 姜树林
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com