2 results about "Iobenzamic acid" patented technology

The present application relates to a kind of 2-methoxy-4-acetylamino-5-iodobenzoic acid methyl ester preparation method, steps include: S1, by p-aminosalicylic acid and acetic anhydride reaction, preparation 4-acetylamino salicylic acid;S2, by the 4-acetylamino salicylic acid and dimethyl sulfate reaction, preparation 2-methoxy-4-acetylamino benzoic acid methyl ester;S3, by the 2-methoxy-4-acetylamino benzoic acid methyl ester and iodine reaction, preparation 2-methoxy-4-acetylamino-5-iodobenzoic acid methyl ester.The preparation method of the present application is compared with prior art, and reaction step is shortened to three steps, and total yield is as high as 70% or so;While the yield of iodine substitution reaction is increased from 29% to more than 90%.

This invention discloses a method for preparing 2-carboxylic acid diphenyl iodide ester. The method involves using 2-iodobenzoic acid and benzene as raw materials in an acidic solvent, with potassium persulfate and a heteropolyacid metal salt as a mixed catalyst, and controlling the reaction temperature at 10℃~20℃ to synthesize 2-carboxylic acid diphenyl iodide ester. The product is then purified. The mass ratio of 2-iodobenzoic acid, benzene, and the mixed catalyst in this invention is 250:85~95:2~5. The synthetic route is simple, and the purity of the prepared product is over 99.9%, meeting the high purity requirements of electronic chemical raw materials. The yield can reach approximately 90%, demonstrating high industrial application value. Furthermore, the catalyst used in this invention can be recycled, further reducing production costs.