A kind of polyethylene glycol monomethyl ether modified mesoporous silica nanoparticles and its preparation method and application

A technology of polyethylene glycol monomethyl ether and mesoporous silica, applied in the field of medicine

Active Publication Date: 2016-08-17
武汉格迪泰健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mesoporous silica nanoparticles modified with polyethylene glycol monomethyl ether have not been reported yet.

Method used

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  • A kind of polyethylene glycol monomethyl ether modified mesoporous silica nanoparticles and its preparation method and application
  • A kind of polyethylene glycol monomethyl ether modified mesoporous silica nanoparticles and its preparation method and application
  • A kind of polyethylene glycol monomethyl ether modified mesoporous silica nanoparticles and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Preparation of polyethylene glycol monomethyl ether acrylate-dithiothreitol

[0051] Polyethylene glycol monomethyl ether (1000, 12.5g, 12.5mmol) was dissolved in 125mL of toluene, argon was passed through, azeotropic distillation was carried out, and about 100mL of toluene was removed. Argon was blown, cooled to room temperature, and then anhydrous dichloromethane was added until the solution was clarified to form a clear solution.

[0052] Triethylamine (2.61mL, 18.75mmol) was added dropwise into the clear solution, and after stirring evenly, 1.60mL of acryloyl chloride (18.75mmol) was added and reacted overnight under nitrogen gas. The product was filtered in vacuo until clear and diethyl ether was added to form a precipitate. The precipitate was collected by filtration and dried in vacuo.

[0053] Dissolve 20 g of the precipitate in 200 mL of deionized water, adjust the pH to 6.0 with NaOH, and extract three times with 100 mL of dichloromethane. Collect the d...

Embodiment 2

[0061] (1) Preparation of MSNs-SH

[0062] Polyethylene glycol monomethyl ether (20000, 250g, 12.5mmol) was dissolved in 125mL of toluene, argon was passed through, azeotropic distillation was carried out, and about 100mL of toluene was removed. Cool at room temperature with argon gas, cool with ice water, and then add an appropriate amount of anhydrous dichloromethane until the solution is clear to obtain a clear solution.

[0063] Add triethylamine (2.61mL, 18.75mmol) dropwise to the clear solution, stir, then add 3.2mL (37.5mmol) acryloyl chloride, react overnight, blow nitrogen, filter in vacuo until clear, then add diethyl ether to make it Precipitation was collected by filtration and dried in vacuo.

[0064] Dissolve 20 g of the precipitate in 200 mL of deionized water, adjust the pH to 6.0 with NaOH, and extract three times with 100 mL of dichloromethane. The dichloromethane-washed extract was collected, and diethyl ether was added to the extract to form a precipitate...

Embodiment 3

[0072] (1) Preparation of polyethylene glycol monomethyl ether acrylate-dimercapto compound

[0073] Polyethylene glycol monomethyl ether (10000, 125g, 12.5mmol) was dissolved in 125mL of toluene, argon was passed through, azeotropic distillation was carried out, and about 100mL of toluene was removed. Cool at room temperature with argon gas, cool with ice water, and then add an appropriate amount of anhydrous dichloromethane until the solution is clear to obtain a clear solution.

[0074] Triethylamine (2.61 mL, 18.75 mmol) was added dropwise to the clear solution, stirred, and then 1.28 mL (15 mmol) of acryloyl chloride was added, and the reaction was carried out overnight under nitrogen gas. The product was filtered in vacuo until clear and precipitated by addition of diethyl ether. The precipitate was collected by filtration and dried in vacuo.

[0075] Dissolve 20 g of the precipitate in 200 mL of deionized water, adjust the pH to 6.0 with NaOH, and extract three times ...

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Abstract

The invention relates to a mesoporous silicon dioxide nanoparticle modified with polyethylene glycol monomethyl ether, a preparation method and application thereof, and belongs to the technical field of medicine. The preparation method of polyethylene glycol monomethyl ether modified mesoporous silica nanoparticles is as follows: (1) Preparation of polyethylene glycol monomethyl ether acrylate-dimercapto compound; (2) Mercaptopropyl modified mesoporous Preparation of silica nanoparticles; (3) Preparation of mesoporous silica nanoparticles modified with polyethylene glycol monomethyl ether. The average particle size of the product is 50-500nm, and it can be used as a silica nano-carrier for delivering anti-tumor drugs, thereby effectively treating related cancers; the preparation method is simple and easy, and the raw materials are cheap and easy to obtain.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a mesoporous silica nanoparticle modified with polyethylene glycol monomethyl ether and its preparation method and application. Background technique [0002] Compared with the traditional controlled release system, the main advantages of the drug controlled release drug delivery system are: it can improve the bioavailability of the drug; it can reduce the toxicity of the drug; it can enhance the therapeutic effect of the drug; it can improve the stability of the drug, etc. [0003] Mesoporous silica has the characteristics of uniform pore size, easy surface modification, and good biocompatibility, and has attracted extensive attention in the field of drug delivery systems. In 1992, Kresge and others synthesized the MCM-41 mesoporous molecular sieve for the first time, which has applications in catalysis, adsorption, chemical imaging, etc., and has developed rapidly. Since this ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/00C08G65/48A61K47/34A61K45/00A61P35/00
Inventor 刘明星谢志飞
Owner 武汉格迪泰健康科技有限公司
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