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Solid lipid nanometer particle for astaxanthin and preparation method of solid lipid nanometer particle

A technology of solid lipid nano and astaxanthin, which is applied in the field of medicine, can solve the problems of poor stability and low solubility of astaxanthin, and achieve the advantages of not easy isomerization and degradation, improved absorption rate and bioavailability, and good stability Effect

Active Publication Date: 2015-01-07
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main purpose of the present invention is to provide a solid lipid nanoparticle of astaxanthin and its preparation method to solve the problems of low solubility and poor stability of astaxanthin in water

Method used

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  • Solid lipid nanometer particle for astaxanthin and preparation method of solid lipid nanometer particle

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preparation example Construction

[0033] The embodiment of the present invention also provides a preparation method of astaxanthin solid lipid nanoparticles, comprising:

[0034] Step S101, mixing the solid fat and vegetable oil, heating and stirring at a constant temperature until fully mixed, to obtain a clear and uniform oily liquid, which is the first mixed oil phase;

[0035] Step S102, adding astaxanthin to the first mixed oil phase, and under the protection of nitrogen, continue heating and stirring at a constant temperature to fully mix to obtain an oily liquid, which is the second mixed oil phase;

[0036] Step S103, fully mixing the surfactant and deionized water to obtain a clear aqueous solution, which is the water phase;

[0037] Step S104, dispersing the second mixed oil phase into the water phase drop by drop until the dispersion is complete, and high-shearing at room temperature to obtain an opaque emulsion suspension, which is a coarse emulsion of astaxanthin;

[0038] Step S105, performing h...

Embodiment 1

[0043] Step 1: Accurately weigh 0.05g of stearic acid and 4.95g of soybean oil, place them in a test tube, put the test tube into a water bath magnetic stirrer, set the temperature at 75°C, adjust the speed to 500rpm, and heat for 1 hour to make stearin Dissolve the acid in soybean oil and mix it thoroughly to obtain a milky yellow oily liquid, which is the first mixed oil phase;

[0044] Step 2: Accurately weigh 5 mg of astaxanthin purple crystals (purity>99%), add it to the first mixed oil phase, and at the same time continue to feed nitrogen, continue mixing under the protection of nitrogen, set the temperature to 75 ° C, adjust the speed to 500rpm, heating for 15min, so that astaxanthin is dissolved in stearic acid and soybean oil, and fully mixed with them to obtain a purple oily liquid, which is the second mixed oil phase;

[0045]Step 3: Accurately weigh 5g of surfactant Tween 20 and 50g of deionized water, put them in an 80ml beaker, place the beaker on a magnetic stir...

Embodiment 2

[0058] Step 1: Accurately weigh 0.05g of glyceryl monostearate and 4.95g of soybean oil, place them in a test tube, put the test tube into a water bath magnetic stirrer, set the temperature to 75°C, adjust the speed to 500rpm, and heat for 1h. Glyceryl monostearate is dissolved in soybean oil and fully mixed with it to obtain a milky yellow oily liquid, which is the first mixed oil phase;

[0059] Step 2: Accurately weigh 5 mg of astaxanthin purple crystals (purity>99%), add it to the first mixed oil phase, and at the same time continue to feed nitrogen, continue mixing under the protection of nitrogen, set the temperature to 75 ° C, adjust the speed to 500rpm, heating for 15min, so that astaxanthin is dissolved in glycerol monostearate and soybean oil, and fully mixed with it to obtain a purple oily liquid, which is the second mixed oil phase;

[0060] Step 3: Accurately weigh 5g of surfactant Tween 20 and 50g of deionized water, put them in an 80ml beaker, place the beaker o...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a solid lipid nanometer particle for astaxanthin and a preparation method of the solid lipid nanometer particle. The solid lipid nanometer particle for the astaxanthin is prepared from lipid materials and an aqueous phase according to a weight ratio of 1:11, wherein the lipid materials comprise the following components in percentage by weight: 1-15% of solid fat, 85-98.9% of vegetable oil and 0.1% of astaxanthin; the aqueous phase comprises the following components in percentage by weight: 1-10% of surfactants and 90-99% of deionized water. A lipid kernel is arranged in the solid lipid nanometer particle provided by the invention, the aqueous phase is arranged outside the solid lipid nanometer particle for the astaxanthin, and the solubility of the astaxanthin in water is increased, so that the absorptivity and the bioavailability of fat-soluble components, i.e., the astaxanthin, in gastrointestinal tracts are improved; moreover, the solid lipid nanometer particle for the astaxanthin is in a subtransparent state, the indexes of emulsion, such as the average particle diameter, the Zeta electric potential and the dispersion index PDI, are good, isomerase and degradation are not easy to generate, and the solid lipid nanometer particle for the astaxanthin has better stability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an astaxanthin solid lipid nanoparticle and a preparation method thereof. Background technique [0002] Astaxanthin is a purple crystal with the molecular formula C 40 h 52 0 4 , with a relative molecular weight of 596.86, is a terpene-like unsaturated compound that belongs to the xanthophyll-β-carotene family. Natural astaxanthin has a strong antioxidant capacity, can effectively remove oxygen free radicals in cells, and prevent tissues, cells, and DNA from being oxidatively damaged. It is called "super vitamin E". At the same time, astaxanthin also has physiological activities such as anti-aging, anti-tumor and prevention of cardiovascular and cerebrovascular diseases, and has important application value in industries such as food, health products, pharmaceuticals and cosmetics. [0003] Astaxanthin is a fat-soluble component with low solubility in water, resu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/122A61P39/06A61P35/00A61P9/10
Inventor 梁浩李苗苗袁其朋
Owner BEIJING UNIV OF CHEM TECH
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