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Alcohol extract of cistanche deserticola, preparation method and use thereof

A technology of Cistanche Alcohol and its extracts, which is applied in the field of medicine, can solve the problems of weak coordination effect and inaccurate curative effect, and achieve the effect of improving the quality of life, strong drug coordination effect, and inhibiting the incidence of radiation pneumonitis

Active Publication Date: 2017-09-05
内蒙古中兴华冠生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coordination effect of each Chinese medicine in the Chinese medicine composition is not strong, and the curative effect is not exact

Method used

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  • Alcohol extract of cistanche deserticola, preparation method and use thereof
  • Alcohol extract of cistanche deserticola, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1, a kind of method that prepares cistanche alcohol extract from cistanche bark:

[0054] (1) Peel the fresh Cistanche, dry the obtained Cistanche skin at 40°C, crush the dried Cistanche skin, pass the powder through a 80-mesh sieve, add 75% ethanol 8 times the powder weight to the powder, and ultrasonic (25KHz) Extract for 30 minutes, filter, and carry out secondary extraction on the filter residue, add 65% ethanol 6 times the weight of the powder to the filter residue, ultrasonic (25KHz) extract for 30 minutes, filter, combine the two filtrates, and rotate the filtrate to obtain the cistanche cistanche alcohol extract concentrate.

[0055] (2) Select an ultrafiltration membrane with a molecular weight cut-off of 5000Da, and perform ultrafiltration on the concentrated solution of the cistanche deserticola extract obtained in step (1) at a pH value of 8.0, a temperature of 45°C, and a pressure of 0.8 MPa, and collect the filtrate for 60 Concentrate at ℃ to ob...

Embodiment 2

[0057] Embodiment 2, pharmaceutical composition of the present invention and preparation process:

[0058] Parts by weight of the pharmaceutical composition: 6 parts of cistanche alcohol extract, 6 parts of radish seed, 9 parts of rhubarb rhizome, 17 parts of rhubarb, 9 parts of Phellodendron cortex, 10 parts of salvia miltiorrhiza, 3 parts of Polygonatum, 3 parts of Ligustrum lucidum, 6 parts of Polygonum multiflorum, 6 parts of Jen, 5 parts of Epimedium, 15 parts of Lycium barbarum, 12 parts of Angelica dahurica, 12 parts of Galla chinensis, 14 parts of cicada slough, 6 parts of Piper barbatus, 5 parts of Cuscuta seed, 20 parts of Angelica sinensis and 10 parts of licorice.

[0059] Take the prescription amount of the above-mentioned medicinal materials and crush them into fine powder, except for the alcohol extract of Cistanche cistanche, add an ethanol solution with a volume concentration of 80% according to 6 times the total weight of the coarse powder, reflux and extract ...

Embodiment 3

[0060] Embodiment 3, pharmaceutical composition of the present invention and preparation process:

[0061] Parts by weight of the pharmaceutical composition: 10 parts of cistanche alcohol extract, 10 parts of radish seed, 5 parts of rhubarb rhizome, 12 parts of rhubarb, 7 parts of cortex cortex, 12 parts of salvia miltiorrhiza, 6 parts of Polygonatum, 7 parts of Ligustrum lucidum, 8 parts of Polygonum multiflorum, 10 parts of kernels, 7 parts of epimedium, 11 parts of medlar, 10 parts of angelica, 15 parts of gall, 12 parts of cicada, 8 parts of Piper chinensis, 7 parts of dodder, 15 parts of angelica and 15 parts of licorice.

[0062] Take the prescription amount of the above-mentioned medicinal materials and crush them into fine powder, except for the cistanche deserticola extract, add an ethanol solution with a volume concentration of 90% according to 7 times the total weight of the coarse powder, reflux and extract three times, the reflux time is 3h, filter, and the obtaine...

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Abstract

The invention provides an extracting method for extracting desertliving cistanche alcohol extracts in desertliving cistanche peel, a desertliving cistanche alcohol extract obtained according to the method, and use of the desertliving cistanche alcohol extract. The method comprises the following steps: using the desertliving cistanche peel, baking and crushing the desertliving cistanche peel, and performing ultrasonic extraction, ultrafiltration and purification, so as to obtain the desertliving cistanche alcohol extract of which the molecular weight is smaller than 5000 Dalton; performing concerted application on the desertliving cistanche alcohol extract, radish seeds, rhizoma coptidis, Chinese rhubarb, phellodendron, radix salviae miltiorrhizae, rhizoma polygonati, glossy privet fruits and the like, so as to obtain the medical composition disclosed by the invention; researching the medical composition in the respects of treating and preventing radioactive pneumonia for postradiotherapy, improving the organism immunity, and the like. The extracting method disclosed by the invention increases the utilization of desertliving cistanche which belongs to the rare medicinal materials in imminent danger, so that the desertliving cistanche has a higher economic value, and the extracting method provides a medical composition which has the advantages of high efficiency, low toxicity and low cost, and is easy to generalize for vast patients with tumors.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a method for extracting an alcohol extract of Cistanche deserticola from bark of Cistanche deserticola, the alcohol extract of Cistanche deserticola obtained by the method, and the use of the alcohol extract of Cistanche deserticola. Background technique [0002] Cistanche deserticola (Cistanche deserticola Y.C.Ma) is the dry succulent stem with scaly leaves of Cistanche deserticola (Orobanchaeceae) plant Cistanche. The reputation of "Desert Ginseng" was first recorded in "Shen Nong's Materia Medica", listed as top grade, and is one of the commonly used traditional Chinese medicines. There are about 18 species of this genus in the world, and there are about 4 species and 1 variant in my country, which are Cistanche, Salina, Cistanche, White-flowered Cistanche and Cistanche. Except Cistanche, the other 4 species are mainly produced in Provinces in Northwest my country....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61K36/64A61P35/00A61P39/00A61P11/00A61K35/64
CPCA61K36/232A61K36/296A61K36/31A61K36/39A61K36/484A61K36/537A61K36/638A61K36/64A61K36/67A61K36/704A61K36/708A61K36/718A61K36/756A61K36/815A61K36/8969A61K36/9064A61K2236/13A61K2236/17A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 孙喜翠
Owner 内蒙古中兴华冠生物工程股份有限公司