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Amino acid Schiff base ligand silver complex and its preparation method and antibacterial application

A technology of silver complexes and Schiff bases, applied in the fields of botanical equipment and methods, silver organic compounds, applications, etc., can solve the problems of insufficient stability of silver ions, discoloration, and reduced antibacterial ability.

Active Publication Date: 2016-06-08
兴化市润海文化旅游发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the silver ion is not stable enough, it will be transformed into metallic silver or silver oxide to produce discoloration, which reduces its antibacterial ability and limits its application to a certain extent.

Method used

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  • Amino acid Schiff base ligand silver complex and its preparation method and antibacterial application
  • Amino acid Schiff base ligand silver complex and its preparation method and antibacterial application
  • Amino acid Schiff base ligand silver complex and its preparation method and antibacterial application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Salicylaldehyde L-histidine Schiff base silver complex {Ag(L 1 )} n Preparation.

[0016] Salicylaldehyde L-histidine Schiff base ligand HL 1 (1mmol, 0.26g) dissolved in 40mL methanol, AgNO was added to the solution 3 (1mmol, 0.17g) aqueous solution 10mL, stirred for about 10min, white precipitate formed, then filtered, washed with water, vacuum dried to obtain the salicylaldehyde L-histidine Schiff base silver complex (yield 68% ): IR(KBr,cm -1 )3463(ms),3380(s),3220(s),3030(s),1786(s),1650(vs),1530(s),1297(s),1211(s),1098(s) ,1004(s),967(s),886(s),583(s).

Embodiment 2

[0017] Example 2: Reduced salicylaldehyde L-histidine Schiff base silver complex Ag 2 (L 2 ) 2 ·3H 2 O's preparation.

[0018] Step 1: Condensate salicylaldehyde with L-histidine Schiff base ligand HL 1 (2mmol, 0.52g) dissolved in 50mL methanol, under ice bath conditions, add solid NaBH in batches 4 (3mmol, 0.11g), react for 1~1.5h until no gas is released, and then distill under reduced pressure to remove 4 / 5 of the solvent. After adding 50mL of distilled water to the resulting solution at room temperature, add 6mol / L HCl solution dropwise to adjust the pH value to about 3~4, and a large amount of white precipitate is precipitated. After filtering, washing and drying, reduced salicylaldehyde L- Histidine Schiff base ligand HL 2 (Yield 63%).

[0019] Step 2: Recondensate reduced salicylaldehyde with L-histidine Schiff base ligand HL 2 (0.2mmol, 0.026g) dissolved in 20mL methanol, AgNO was added to the solution 3 (0.2mmol, 0.017g) aqueous solution 5mL, after stirring for 0.5h, a yel...

Embodiment 3

[0023] Example 3: In vitro antibacterial experiment.

[0024] Step 1: Experimental materials.

[0025] 1.1 Strains: Serratia marcescens (jn01), yeast (jn05), Bacillus subtilis (JN-16) are preserved by the Animal Medicine Laboratory of Jilin Agricultural University; Mycobacterium smegmatis (mc 2 155) Purchased from China Veterinary Drug Supervision Institute.

[0026] 1.2 Preparation of liquid medicine

[0027] Weigh 12.8mg of the solid drug, dissolve it with 12.5μL of dimethylformamide (DMF), add 300μL of sterilized double-distilled water to dilute to a concentration of 40960μg / mL, take 10μL of the dissolved drug solution and add 90μL of double-distilled water to dilute 10 At this time, the concentration is 4096μg / mL.

[0028] 1.3 Bacterial culture and counting

[0029] Connect the tested bacteria to the corresponding liquid culture medium, and after they grow to the logarithmic growth phase, take a small amount and count them with the plate coating method, and place the remaining bacte...

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Abstract

The invention provides two complexes formed by a salicylaldehyde L-histidine schiff base ligand, a reduced ligand of the salicylaldehyde L-histidine schiff base ligand and silver, and a preparation method and an antibacterial application of the complexes. The two silver complexes can be represented by general formulas {Ag(L<1>)}n and Ag2(L<2>)2.3H2O, wherein the structural formulas of L<1> and L<2> are as shown in the figure. The preparation method comprises the following steps: firstly, restoring C=N double bonds in the salicylaldehyde L-histidine schiff base ligand (HL<1>) into a C-N single bond by using NaBH4 to obtain a reduced ligand (HL<2>); and then enabling the two ligands to respectively act together with AgNO3 to obtain two silver complexes. The amino acid schiff base ligand silver complexes provided by the invention are brand new in structure and simple in preparation method, have significant antibacterial activity, and are expected to be applied to antibacterial materials and antibacterial medicines.

Description

Technical field [0001] The invention relates to the field of transition metal complex materials, in particular to silver-based antibacterial complexes and preparation methods and applications. The two silver complexes have strong antibacterial activity and are expected to be used in antibacterial materials and antibacterial drugs. technical background [0002] With the improvement of people's living standards and the strengthening of health awareness, antibacterial products have become an indispensable part of people's lives. Since silver ions are safe and non-toxic to human cells and immune systems, and have excellent antibacterial properties, silver ions and their compounds are usually used to prepare inorganic antibacterial agents. At present, silver-based inorganic antibacterial agents are widely used in various fields such as chemical fiber, plastic products, building materials, glass, ceramics, coatings, water treatment, cosmetics and so on. According to the different mech...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/10A01N55/02A01P1/00A01P3/00A61K31/555A61P31/04A61P31/10
CPCA01N55/02C07D233/64C07F1/005
Inventor 刘海燕黄守磊田军王广慧赵东江孙红梅
Owner 兴化市润海文化旅游发展有限公司