Method and device for extracting erythromycin thiocyanate

A technology of erythromycin thiocyanate and an extraction method, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low product purity and low product yield, and achieve high purity, high high yield effect

Inactive Publication Date: 2015-01-07
JIANGSU JIUWU HITECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem solved by the present invention is: product purity is not high, product yield is low in the existing erythromycin thiocyanate production technology

Method used

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  • Method and device for extracting erythromycin thiocyanate

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Effect test

Embodiment 1

[0052]Take 100L of erythromycin fermentation broth and heat it up to 65°C, and then filter it through a titanium oxide ceramic ultrafiltration membrane. Send the ultrafiltration permeate to the nanofiltration membrane for concentration. The material of the nanofiltration membrane is sulfonated polysulfone, the molecular weight cut-off is 200Da, the nanofiltration temperature is 50°C, and the pressure is 1.4MPa. Concentrate and concentrate 8 times to obtain a concentrated solution , then add the acetone of concentrated solution volume 1 / 4 wherein, carry out extraction, separate the organic phase, flow the sodium thiocyanate solution of 20wt.% in the organic phase (add 0.4 mole of thiocyanate in every 1 mole of erythromycin thiocyanate), and then adjust the pH to about 7.5 with 50% glacial acetic acid solvent, add purified water according to 1 times the volume of the organic phase, control the crystallization temperature at 25-30°C, stir slowly for 10 minutes, let stand for 4 hou...

Embodiment 2

[0054] Take 100L of erythromycin fermentation broth and heat it up to 65°C, filter it with an alumina microfiltration membrane, the average pore size of the microfiltration membrane is 200nm, and filter the microfiltration permeate through a titanium oxide ceramic ultrafiltration membrane, the average pore size of the ultrafiltration membrane is The transmembrane pressure is 20nm, the transmembrane pressure difference is 0.2MPa, and the membrane surface flow rate is 2m / s. After being concentrated 8 times, the ultrafiltration permeate is sent to the nanofiltration membrane for concentration. The material of the nanofiltration membrane is sulfonated polysulfone, and the molecular weight cut off 200Da, nanofiltration temperature 50°C, pressure 1.4MPa, concentrate, concentrate 8 times to obtain a concentrated solution, then add acetone with 1 / 4 of the concentrated solution volume to it for extraction, separate the organic phase, and add 20wt to the organic phase .% sodium thiocyana...

Embodiment 3

[0056] Take 100L of erythromycin fermentation broth and heat it up to 55°C, and filter it through a titanium oxide ceramic ultrafiltration membrane. The ultrafiltration permeate is sent to the nanofiltration membrane for concentration. The material of the nanofiltration membrane is polyamide, sulfonated polysulfone, polyacrylonitrile, sulfonated polyethersulfone and polyimide, and the molecular weight cut-off is 200Da. Concentrate at a temperature of 40°C and a pressure of 2.0MPa, and concentrate 8 times to obtain a concentrated solution, then add acetone with 1 / 4 of the concentrated solution volume to it for extraction, separate the organic phase, and add 20wt.% sulfur to the organic phase Sodium cyanate solution (add 0.4 moles of sodium thiocyanate to 1 mole of erythromycin), adjust the pH to about 7.5 with 50% glacial acetic acid solvent, add purified water by 1 times the volume of the organic phase, and control the crystallization temperature at 25 Stir slowly at ~30°C for...

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Abstract

The invention provides a method and device for extracting erythromycin thiocyanate. The method comprises the following steps: filtering erythromycin fermentation liquor by using an ultrafiltration membrane so as to remove impurities and colors, carrying out further impurities and colors removal on filter liquor by using the ultrafiltration membrane, concentrating filter liquor by using a nanofiltration membrane, and finally, carrying out extraction on the obtained product by using a recrystallization process, so that the high-purity erythromycin thiocyanate is obtained. Compared with traditional erythromycin thiocyanate extraction processes, the method and device disclosed by the invention have the advantages that the yield of extracted erythromycin A is high; the purity of the extracted erythromycin A is high; an operation process is simplified; and the solvent cost is reduced, the industrial pollution is less, and the like.

Description

technical field [0001] The invention relates to a method and a device for extracting erythromycin thiocyanate, belonging to the technical field of pharmaceutical engineering. Background technique [0002] Erythromycin thiocyanate (referred to as sulfur red) is the thiocyanate of erythromycin, which is the basis of domestic erythromycin derivative products such as roxithromycin, erythromycin ethylsuccinate, azithromycin, clarithromycin, etc. raw material. Due to the large number of clinical applications of erythromycin and its derivatives, it has become the third largest drug in the world's antibiotic market, so the market demand for erythromycin thiocyanate as its synthetic raw material is also extremely high at home and abroad. with rising. Erythromycin is a multi-component antibiotic. In addition to the active component erythromycin A, it also includes isomeric by-products such as erythromycin B, C, D, E, and F. Erythromycin C is very similar to A in structure, and it i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H17/08C07H1/06
Inventor 彭文博熊福军丁邦超杨积衡王伟张宏
Owner JIANGSU JIUWU HITECH
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