Resorbable cellulose based biomaterial and implant

Abstract

The present disclosure describes an implant for tissue replacement or augmentation including a resorbable non-pyrogenic porous body of irradiated oxidized cellulose, formed from a precurosr reactive mixture of irradiated cellulose and an oxidizing agent, where the body forms a heterogeneous three-dimensional fibrillar network. Also disclosed is a method for producing a body of oxidized cellulose including irradiating a body of cellulose to form an irradiated body of cellulose, and reacting the irradiated body of cellulose with an oxidizing agent to form a non-pyrogenic porous and resorbable body of oxidized cellulose.

Description

[0001] Cross references to related patent applications [0002] This patent application claims priority to US Provisional Patent Application Serial No. 61 / 601,653, filed February 22, 2012, the disclosure of which is hereby incorporated by reference as if set forth in its entirety herein. technical field [0003] The present disclosure relates to absorbent, porous, and compliant biomaterials useful as medical implants, and to a method of controlled oxidation of gamma-irradiated cellulose to provide the biomaterials. The implant may be formed as a sheet or patch for tissue replacement or augmentation, especially for soft tissue indications, and more particularly for use with the dura mater. Background technique [0004] Dural repair (duraplasty) is indicated following traumatic, neoplastic, inflammatory lesions, surgical resection, or congenital deletions. Dural replacement is used in cranial surgery where primary closure of the natural meninges is not possible. Historically...

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Problems solved by technology

[0009] Although methods for oxidizing cellulose are widely described in the literature, they generally fail to produce homogeneous oxidized materials with the most desirable properties for medical applications

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