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Hydroxypropyl methylcellulose hollow capsule and production process thereof

A technology of hypromellose and hollow capsules, applied in the direction of capsule transportation, etc., can solve the problems of large water content differences and low water content of plant fibers, and achieve low water content, good safety, and good film-forming properties

Inactive Publication Date: 2015-02-04
ZHEJIANG CHUNBAO CAPSULES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems in the prior art, and propose a hypromellose hollow capsule and its production process, which overcomes the shortcomings of large water content differences caused by low water content of plant fibers, and has good performance and high safety. , less affected by external temperature and humidity

Method used

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  • Hydroxypropyl methylcellulose hollow capsule and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: transparent colorless hypromellose hollow capsule

[0061] Measured to produce 1000 capsules, fully transparent capsules, no pigment and titanium dioxide mother liquor are required in the raw materials.

[0062] Take 500g of warm purified water, add 120g of HPMC to it, stir while adding, heat the purified water to raise the temperature to 90°C, keep stirring to make the HPMC evenly dispersed, after the HPMC dissolves, lower the temperature to 50°C, and let it stand 12 hours, set aside.

[0063] Take 130g of warm water, add sodium lauryl sulfate until dissolved, add carrageenan, stir while adding, and heat to 50°C.

[0064] There is HPMC raw liquid water in the reaction pot which has been left to stand for 12 hours, add carrageenan to it, raise the temperature of the reaction pot to 60°C, stir for 30 minutes, measure the parameters, stand for 1 hour, and set aside.

[0065] Pour the pre-prepared auxiliary solution, that is, the solution containing sodium ...

Embodiment 2

[0067] Embodiment 2: white and red hypromellose hollow capsules

[0068] Measured to produce 1000 capsules.

[0069] Weigh TiO 2 10g, prepare purified water 100g, will TiO 2 Add water into the grinder, keep the temperature of the grinder at 40°C, set the speed of the grinder to 800 rpm, and grind for 20 minutes. Filter the ground powder with a 250-mesh silk bag, then add purified water at 80°C to prepare Titanium dioxide mother liquor, total liquor is 110g.

[0070] Take 500g of warm purified water, add 120g of HPMC to it, stir while adding, heat the purified water to raise the temperature to 90°C, keep stirring to make the HPMC evenly dispersed, after the HPMC dissolves, lower the temperature to 50°C, and let it stand 12 hours, set aside.

[0071] Take 130g of warm water, add sodium lauryl sulfate until dissolved, add carrageenan, stir while adding, and heat to 50°C.

[0072] There is HPMC raw liquid water in the reaction pot which has been left to stand for 12 hours, ad...

Embodiment 3

[0077] Embodiment 3: all red hypromellose hollow capsules

[0078]The process equipment and raw material composition used are basically the same as in Example 2, the only difference is that the raw material pigment carmine is 0.128g, and the pigment solution and titanium dioxide mother liquor 10g are added to the glue solution together.

[0079] The hollow capsule prepared in this embodiment can be completely disintegrated within 10 minutes of gastric dissolution, and is resistant to high temperature, high humidity and cold.

[0080] Working process of the present invention:

[0081] A kind of hypromellose hollow capsule of the present invention and production process are in the working process, through the proportioning of hypromellose, surfactant, coagulation aid i.e. sodium lauryl sulfate, carrageenan, preparation process Hypromellose hollow capsules are produced by adopting high-temperature mixing and high-temperature drying technology, which is opposite to the low-temper...

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Abstract

The invention discloses a hydroxypropyl methylcellulose hollow capsule and a production process thereof. The glue solution of the hollow capsule is prepared from the following components: 120.0g of hydroxypropyl methylcellulose HPMC, 3.5g of carrageenan, 10.0g of titanium dioxide mother liquor, 0.08g of lauryl sodium sulfate, 530.0g of pure water and 0-0.15g of pigment. The production process comprises the following steps: preparing the titanium dioxide mother liquor; preparing HPMC sol; adding pigment into the glue solution; dipping glue, baking, demolding, cutting, registering, inspecting, packaging and putting in storage. The preparation process is simple and strong in operability, the capsule product has good molding property, high safety, good reliability and low water content, effectively takes the curative effect of content, is stable in molecule transmission, does not perform crosslinking reaction with the content, is sufficient in solubility, is little impacted by external temperature and humidity, has long preservation period, and is convenient for transporting and storing.

Description

【Technical field】 [0001] The invention relates to the technical field of medical preparation production, in particular to the technical field of hypromellose hollow capsules. 【Background technique】 [0002] At present, hard hollow capsules are widely used as drug carriers. Usually, gelatin is soaked in water, swelled, stirred and dissolved in a reaction pot, and then the glue is filtered to adjust the glue concentration, peeled to remove air bubbles, and dipped in the automatic glue dipping production line. Gluing, drying, cooling, demoulding, cutting, fitting, inspection, packaging. [0003] The capsule material of the capsule shell is mainly gelatin. Gelatin is a material derived from animals. The raw material comes from animal skin and bone. Gelatin is animal protein colloid and contains a small amount of animal fat. In recent years, with the occurrence of foot-and-mouth disease, mad cow disease, and bird flu, the safety of gelatin has been increasingly questioned. In a...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38
Inventor 潘苏枫
Owner ZHEJIANG CHUNBAO CAPSULES
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