Polymeric hydrogel fever cooling patch for children and preparation method thereof

A polymer hydrogel and antipyretic patch technology, applied in the field of medicine, can solve the problems of poor skin affinity, short maintenance time, small adhesion and easy to fall off, etc., to achieve fever treatment, obvious effect, and good biocompatibility Effect

Inactive Publication Date: 2015-02-11
ZHEJIANG OYEAH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antipyretic plasters have been widely used in Japan, Europe, America and other countries. However, most of the antipyretic plasters for children in the Chinese market are purely physical cooling, and the maintenance time is short. Moreover, the quality and performance of domestic products are not as good as those of foreign-funded enterprises. Poor skin affinity, low adhesion and easy to fall off, so there is a wide range of research space

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A method for preparing a polymer hydrogel antipyretic patch for children, comprising the following steps: (1) Dissolving 4g of menthol in 6mL of ethanol and mixing uniformly to obtain solution A, dissolving 3g of borneol in 9mL of ethanol and mixing uniformly to obtain solution B ; (2) Add 10g of glycerin, 0.9g of solution A and 5 drops of solution B into 80g of distilled water and mix well to obtain solution C; (3) slowly add 10g of sodium polyacrylate powder to solution C and stir until fully swollen to obtain Hydrogel; (4) Coat the hydrogel on the non-woven fabric, the coating thickness is 0.35mm, and cut the semi-finished antipyretic patch; (6) After the semi-finished antipyretic patch is placed at room temperature for 24 hours, press it Adhesive layer, packaged to obtain the finished product of cooling paste.

Embodiment 2

[0018] A method for preparing a polymer hydrogel antipyretic patch for children, comprising the following steps: (1) dissolving 0.5g of menthol in 2mL of ethanol and mixing uniformly to obtain solution A; (2) mixing 6g of glycerin, 5g of propylene glycol, and 2g of olive Add oil and solution A to 85g of distilled water and stir to obtain solution C; (3) Add 1g of sodium alginate to distilled water at a temperature of 80°C, and cool down to obtain hydrogel I after the sodium alginate is fully dissolved; ( 4) Slowly add 12g of sodium polyacrylate powder to solution C one by one and stir evenly until fully swollen to obtain hydrogel II, mix hydrogel I and hydrogel II evenly to obtain a hydrogel layer and cool to room temperature; ( 5) Coat the non-woven fabric with a hydrogel layer, the coating thickness is 0.5mm, and cut the semi-finished product of the antipyretic patch; (6) After the semi-finished product of the antipyretic patch is placed at room temperature for 24 hours, pres...

Embodiment 3

[0020] A method for preparing a polymer hydrogel antipyretic patch for children, comprising the following steps: (1) dissolving 5 g of menthol in 10 mL of ethanol and mixing uniformly to obtain solution A; (2) mixing 8 g of glycerin, 2 g of propylene glycol, and 2 g of solution A Add it into 80g of distilled water and mix it evenly to obtain solution C; (3) Add 1g of sodium alginate and 1.5g of sodium carboxymethylcellulose into 17.5g of distilled water at a temperature of 80°C, and wait until the sodium alginate and carboxymethylcellulose After the sodium sulfate is fully dissolved, cool down to obtain hydrogel I; (4) Add 10g of sodium polyacrylate powder to solution C in sequence and stir until fully swollen to obtain hydrogel II, and mix hydrogel I and hydrogel II Uniformly obtain the hydrogel layer and cool to room temperature; (5) Coat the hydrogel layer on the non-woven fabric with a coating thickness of 0.3 mm, and cut the semi-finished antipyretic patch; (6) Put the sem...

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PUM

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Abstract

The invention discloses a polymeric hydrogel fever cooling patch for children, which is composed of a backing layer, an anti-sticking layer and a hydrogel layer, wherein the backing layer is made from non-woven fabric; the anti-sticking layer is a PET film, a PC film or a PU film; the hydrogel layer comprises the following raw materials in percentage: a macromolecular substance, a moisturizing factor, menthol, borneol, distilled water and ethanol; the macromolecular substance is one or more of sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose and polyvinyl alcohol; and the moisturizing factor is one or more of glycerol, propylene glycol, polyethylene glycol and olive oil. The fever cooling patch disclosed by the invention, by loading mass water and little natural freshener in polymeric gel, can achieve effects of cooling and relieving fever; the fever cooling patch integrates functions of physical cooling and cooling through the natural refresher, and has excellent biocompatibility; the fever cooling patch is free from toxic and side effects, safe and reliable, capable of physically cooling and relieving pain, remarkable in fever relieving effect, and simple and feasible in preparation process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a polymer hydrogel antipyretic patch for children and a preparation method thereof. Background technique [0002] Fever in children is a common and frequently-occurring disease. If it is not treated in time, it will affect the health of children. The existing cooling and antipyretic and antipyretic drugs have large side effects, and most of them are oral drugs, which are not conducive to children's use. The antipyretic plaster is an external patch that is pasted on the human skin. It is an external physical cooling method, mainly through the water in the gel to absorb the heat of the human body and vaporize, so as to achieve the effect of cooling with zero side effects. It is a hydrogel made of water-soluble polymer material, which has the advantages of large water content, good air permeability, obvious cooling effect, good biocompatibility with skin, no irritation, and no resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/045A61K47/32A61K47/36A61K47/38A61P29/00A61P43/00
Inventor 彭益文张龙军周奎
Owner ZHEJIANG OYEAH TECH CO LTD
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