Fritillaria superfine powder as well as preparation method and application thereof

A technology of ultra-fine powder and ultra-fine powder, which is used in powder delivery, antibacterial drugs, pharmaceutical formulations, etc. to improve the quality of life, drug safety, and improve the immune function of patients.

Active Publication Date: 2015-02-18
磐安县道地磐药中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to meet the needs of modern health, many time-honored Chinese medicine brands have been formed in the field of traditional Chinese medicine preparations in the process of inheritance, revival and development, such as Rentang (1669), Hu Qingyutang (1874), Dashengxiang (1885), Han Xingtang (1901), Futong (1644 ), Xinghetang (1600), Public Welfare University, Chen Zhiweng, Huaidehe (1948), Old Man Hetai, Weng Changchun (1699), Fu Jichun, Yaguanzhai (Ming Wanli Period), Lei Yunshang and Chinese Medicine Health Tea Time-honored brands such as Wantaiyuan (1860), Zhu Qiansheng, Dapeng Hongri, Qiantaiju, etc. Among them, Wantaiyuan Tea won the gold medal at the 1915 World Exposition of Nations, the first prize at the Philadelphia World Exposition in 1926, and the 1929 Gold Award at the First West Lake Expo, but for the use of Fritillaria in the treatment of pneumothorax, bullae, emphysema, lung shadow, lung cancer, pulmonary heart disease, respiratory failure, pulmonary embolism, lung abscess, pneumonia, neonatal pneumonia, pediatric pneumonia, bronchitis, Asthma, tuberculosis, pneumoconiosis, and / or interstitial lung disease, especially in the treatment of lung cancer, have rarely been reported

Method used

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  • Fritillaria superfine powder as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of Fritillaria superfine powder

[0034] Step 1: Select and clean the materials, select the pearl oysters in the fritillaria of the right size, remove impurities, and the impurity content should not exceed 1%, put the fritillaria after washing and cleaning in the cleaning tank until there is no sediment on the surface until.

[0035] Step 2: dry and sterilize, put the cleaned Fritillaria in a drying room for drying, the temperature of the drying treatment is 85°C, and the drying time is 6 hours; the dried Fritillaria is sterilized, and the sterilized The temperature is 120°C, and the sterilization time is 0.5 hours. Because the pearl oyster in the Fritillaria fritillaria selected for use does not need to remove the core bud when making medicine, under the above-mentioned drying conditions, the moisture of the pearl oyster will volatilize more, and the drying effect is the best. The sterilization condition is set at 120°C and the time is 0.5 hours. At this ...

Embodiment 2

[0041] Preparation of Fritillary Granules

[0042] The Fritillaria superfine powder obtained in Example 1 was added with auxiliary material β-cyclodextrin to make 5000 g of Fritillaria granules, wherein the mass ratio of Fritillaria superfine powder to β-cyclodextrin was 2:1. Among the excipients, Fritillaria and β-cyclodextrin have the best combination effect, and the quality ratio has better drug effect, better taste, and is easier for patients to accept. Among the granules, Fritillaria superfine powder is the only active ingredient.

Embodiment 3

[0044] Clinical Trials

[0045] 1 Materials and methods

[0046] 1.1 Test drugs

[0047] 1.1.1 The prepared Fritillaria granules of embodiment 2

[0048] 1.1.2 Drugs used in the control group

[0049] Drugs purchased from

[0050] Cisplatin Jiangsu Hansoh Pharmaceutical Co., Ltd.

[0051] Pingyangmycin Zhejiang Hisun Pharmaceutical Co., Ltd.

[0052] Bleomycin Zhejiang Hisun Pharmaceutical Co., Ltd.

[0053] Epirubicin Pfizer Pharmaceuticals (Wuxi) Co., Ltd.

[0054] Vincristine Sulfate Yangzhou Aosaikang Pharmaceutical Co., Ltd.

[0055] Vindesine Sulfate Hangzhou Minsheng Pharmaceutical Group Co., Ltd.

[0056] Paclitaxel Yangzijiang Pharmaceutical Group Co., Ltd.

[0057] Cyclophosphamide Shanghai Huashi Pharmaceutical Co., Ltd. Tianping Pharmaceutical Factory

[0058] Ifosfamide Jiangsu Hengrui Medicine Co., Ltd.

[0059] Prednisone Chifeng Mengxin Pharmaceutical Co., Ltd.

[0060] Interferon-a Beijing Kain Biotechnology Co., Ltd.

[0061] Interleukin-2 Shenzh...

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Abstract

The invention discloses fritillaria superfine powder as well as a preparation method and application thereof. The preparation method comprises the following steps: step 1, selecting materials and cleaning; step 2, drying and sterilizing; step 3, grinding and pulping; step 4, pre-freezing slurry; step 5, freezing and drying; step 6, smashing for multiple times into the fritillaria superfine powder with a grain size of 0.5-2 [mu]m. The fritillaria superfine powder is prepared by the preparation method. The fritillaria superfine powder prepared by the preparation method is taken as an only active ingredient to be applied to the preparation of a drug for treating a pulmonary disease. The fritillaria superfine powder disclosed by the invention is used for treating pneumothorax, pulmonary bullous, emphysema, pulmonary shadow, lung cancer, pulmonary heart disease, respiratory failure, pulmonary embolism, pulmonary abscess, pneumonia, neonatal pneumonia, infantile pneumonia, trachitis, asthma, pulmonary tuberculosis, pneumoconiosis and / or interstitial lung disease and has the advantages that the treatment effect is obvious, the condition of a patient is stable, the life quality of the patient is improved, the weight of the patient is increased, the immune function of the patient is improved, and the medication is safe.

Description

technical field [0001] The invention relates to a powder medicine, in particular to a Fritillaria superfine powder and its preparation method and application. Background technique [0002] Fritillaria is a perennial herb, and its bulbs are used for medicine, which can relieve cough and reduce phlegm, clear away heat and resolve stagnation. Alias: Qinmu, Kucai, Kuhua, Kongcao, Yaoshi. Produced in Sichuan, Yunnan, Qinba Mountains in Shaanxi, Gansu and other places. Fritillaria, "The Book of Songs" as a scorpion (sound alliance), "鄘风. Zai Chi": Zhibi Aqiu, the words adopt his scorpion. Mao Heng Chuanyun: 蝱, Fritillaria also. [0003] Fritillaria is a perennial herb of Liliaceae, and its bulbs are used as medicine. Fritillary is slightly cold in nature, sweet and pungent, mainly contains peiminin A, peiminin B and a neutral sterol component, which has the effect of nourishing the lungs, and is mainly used to treat exogenous cough, excessive phlegm, dysphoria, hematemesis, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/14A61P11/00A61P11/06A61P31/06A61P35/00A61P9/00A61P7/02
CPCA61K9/14A61K9/1652A61K36/8966A61K2236/13A61K2236/15A61K2236/17
Inventor 傅苗青周白水朱旭伟何雪心张瑞萍
Owner 磐安县道地磐药中药研究所
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