Preparation method of resveratrol-loaded and amino-modified mesoporous silica nanoparticles

Abstract

The invention relates to a preparation method of resveratrol-loaded and amino-modified mesoporous silica nanoparticles. The method comprises the following steps: weighing amino-modified mesoporous silica nanoparticles, dispersing into a resveratrol saturated ethanol solution, stirring in a dark place at room temperature, carrying out ultrasonic treatment for 3-5 minutes every 20-30 minutes, and stirring for 2-3 hours, so that H2N-MSN (amino-modified mesoporous silica nanoparticles) fully adsorb the RES (resveratrol) saturated ethanol solution; centrifuging for 20-30 minutes at the speed of 15,000-20,000r.min<-1>, and drying the centrifuged white solid under reduced pressure at 35-45 DEG C to obtain drug-loaded powder; repeating the operations of dispersing, adsorbing, centrifuging and drying for 7-8 times, so as to obtain the resveratrol-loaded and amino-modified mesoporous silica nanoparticles. The NH2-MSN (amino-modified mesoporous silica nanoparticles) are successfully synthesized by adopting the improved classical Stober method disclosed by the invention. The drug loading capacity can be effectively increased by virtue of a repeated saturated solution adsorption method; the bioavailability of RES is improved by the prepared NH2-MSN-RES; and the method has a relatively good market prospect.

Description

(1) Technical field [0001] The invention relates to a preparation method of amino-modified mesoporous silica nanoparticles loaded with resveratrol. (2) Background technology [0002] Resveratrol (Resveratrol, RES) is a non-flavonoid polyphenol compound containing stilbene structure extracted from the dried rhizome and root of Polygonum cuspidatum Sieb.et Zucc. [1] . Studies have proved that RES not only has anti-inflammatory and anti-thrombotic effects [2] , and RES inhibits the growth and proliferation of cancer cells, induces the differentiation and apoptosis of cancer cells through anti-oxidation, anti-mutation, inhibition of cyclooxygenase and hydroperoxidase activities, and is known as "paclitaxel". A new green anticancer substance. However, due to its unstable physical and chemical properties, extremely difficult to dissolve in water, and short half-life, the bioavailability of oral preparations is low and the blood concentration is unstable, which severely limits i...

AI Technical Summary

Problems solved by technology

However, due to its unstable physical and chemical properties, extremely difficult to dissolve in water, and short half-life, the bioavailability of oral preparations is low and the blood concentration is unstable, which seriously limits its clinical application.

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