Use of hyperoside in preparation of drug for inhibiting bacterial quorum sensing system

A quorum sensing system, the technology of hyperoside, is applied in the field of chemistry to achieve the effect of reducing bacterial resistance, reducing pathogenicity, and wide market application prospects

Inactive Publication Date: 2015-02-25
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Use of hyperoside in preparation of drug for inhibiting bacterial quorum sensing system
  • Use of hyperoside in preparation of drug for inhibiting bacterial quorum sensing system
  • Use of hyperoside in preparation of drug for inhibiting bacterial quorum sensing system

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Embodiment Construction

[0014] In order to make the purpose, technical scheme and advantages of the present invention clearer, the pharmacological action and effect of hyperin are described in detail below.

[0015] 1. Detection of minimum inhibitory concentration of hyperin on Pseudomonas aeruginosa PAO1

[0016] Take hyperin with a concentration of 200000 μg / mL for doubling dilution, and then add it to a 96-well round-bottom culture plate, so that the concentration of Pseudomonas aeruginosa PAO1 in the plate is OD 600 = 0.05. Place the 96-well plate at 37°C for 24 hours, then take the bacterial solution from each well, inoculate it on LB solid medium, and continue to cultivate at 37°C for 24 hours. The minimum concentration of the drug that is observed without bacterial growth is the minimum concentration of the drug. Inhibitory concentration. The results showed that the minimum inhibitory concentration of hyperin against Pseudomonas aeruginosa PAO1 was 2000 μg / mL.

[0017] 2. Inhibitory effect ...

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Abstract

The invention discloses a use of hyperoside in preparation of a drug for inhibiting a bacterial quorum sensing system. Hyperoside can inhibit a quorum sensing signal molecule thereby reducing bacterial biomembrane formation and virulence factor pathogenicity and reducing bacterial swarming motility so that bacterial resistance to drugs and bacterial pathogenicity are reduced. The hyperoside has low toxicity and use safety.

Description

technical field [0001] The invention belongs to the field of chemistry, and particularly relates to the application of hyperin in the preparation of medicines for inhibiting bacterial quorum sensing systems. Background technique [0002] The use of antibiotics has effectively controlled many serious bacterial infectious diseases in humans, but the widespread use of antibiotics has also led to the increase of drug-resistant strains, reducing the antibacterial efficiency of existing antibiotics. Therefore, it is extremely necessary to develop new antibiotics and establish new treatment models. At present, it is believed that the most promising treatment strategy should not kill the pathogenic bacteria cells but only weaken the pathogenicity of the pathogenic bacteria. This strategy does not threaten the survival of the pathogenic bacteria itself and will not cause drug resistance problems. Recent studies have found that the pathogenicity of pathogenic bacteria is regulated by...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/04
CPCA61K31/7048
Inventor 孙凤军王显凤夏培元陈剑鸿陈盛刘耀冯伟
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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