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Preparation method of resveratrol phospholipid complex self-microemulsion particles

A technology of resveratrol phospholipids and resveratrol, applied in the direction of active ingredients of hydroxyl compounds, medical preparations of non-active ingredients, and pharmaceutical formulas, can solve the problems of poor water dispersion and achieve high bioavailability, The method is simple and the effect of improving solubility

Active Publication Date: 2015-03-04
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the phospholipid complex can improve the lipid solubility of the drug, its dispersion effect in water is not good, especially when the concentration is high, it forms a suspension

Method used

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  • Preparation method of resveratrol phospholipid complex self-microemulsion particles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for preparing resveratrol-phospholipid complex self-microemulsion particles is provided, comprising the steps of:

[0024] (1) At 40°C, weigh 100g of Tween 80, 5g of caprylic / capric triglyceride and 1 part by weight of glycerin to fully mix and form a transparent and uniform blank self-microemulsion;

[0025] (2) At 40°C, weigh 3g of the resveratrol-phospholipid complex, wherein the weight ratio of resveratrol to lecithin in the resveratrol-phospholipid complex is 1:2, add 12g of the step (1 ) in the obtained blank self-microemulsion, stir evenly to form a uniform transparent resveratrol self-microemulsion;

[0026] (3) At 40°C, weigh 1 g of hydroxypropyl methylcellulose, add 9 g of resveratrol self-microemulsion obtained in step (2), and stir well to form a suspension of resveratrol self-microemulsion. Microemulsion;

[0027] (4) At 40°C, weigh 1g of microcrystalline cellulose, add 1g of the suspended resveratrol self-microemulsion obtained in step (3), mix ...

Embodiment 2

[0029] A method for preparing resveratrol-phospholipid complex self-microemulsion particles is provided, comprising the steps of:

[0030] (1) At 50°C, weigh 100g of polyoxyethylene ether (35) castor oil, 15g of caprylic / capric triglyceride and 20g of PEG400 to form a transparent and uniform blank self-microemulsion;

[0031] (2) At 50°C, weigh 3g of the resveratrol-phospholipid complex, wherein the weight ratio of resveratrol to lecithin in the resveratrol-phospholipid complex is 1:4, add 30g of the step (1 ) in the obtained blank self-microemulsion, stir evenly to form a uniform transparent resveratrol self-microemulsion;

[0032] (3) At 50°C, weigh 1g of hydroxypropyl methylcellulose, add 20g of the resveratrol self-microemulsion obtained in step (2), and stir well to form a suspension of resveratrol self-microemulsion. Microemulsion;

[0033] (4) At 50°C, weigh 1.5g of microcrystalline cellulose, add 1g of the suspended resveratrol self-microemulsion obtained in step (3)...

Embodiment 3

[0035]A method for preparing resveratrol-phospholipid complex self-microemulsion particles is provided, comprising the steps of:

[0036] (1) At 60°C, weigh 100g of polyethylene glycol-15-hydroxystearate, 30g of caprylic acid / capric triglyceride and 40g of 1,2-propanediol to form a transparent and uniform blank. Microemulsion;

[0037] (2) At 60°C, weigh 3g of the resveratrol-phospholipid complex, wherein the weight ratio of resveratrol to lecithin in the resveratrol-phospholipid complex is 1:3, add 57g of the step (1 ) in the obtained blank self-microemulsion, stir evenly to form a uniform transparent resveratrol self-microemulsion;

[0038] (3) At 60°C, weigh 1g of hydroxypropyl methylcellulose, add 49g of resveratrol self-microemulsion obtained in step (2), and stir well to form a suspension of resveratrol self-microemulsion. Microemulsion;

[0039] (4) At 60°C, weigh 3g of microcrystalline cellulose, add 1g of the self-suspended resveratrol self-microemulsion obtained i...

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Abstract

The invention discloses a preparation method of resveratrol phospholipid complex self-microemulsion particles. The method comprises the following steps: fully mixing and dissolving a surfactant, caprylic / capric triglyceride and a co-emulsifier at 40-60 DEG C to obtain a blank self-microemulsion; adding a resveratrol phospholipid complex into the blank self-microemulsion, and uniformly stirring to obtain a resveratrol self-microemulsion; adding hydroxypropyl methyl cellulose into the resveratrol self-microemulsion, and uniformly stirring to obtain a suspended resveratrol self-microemulsion; and adding microcrystalline cellulose to ensure that the resveratrol self-microemulsion is transformed into solid-state granular powder so as to obtain a product. By virtue of the mode, the preparation method of the resveratrol phospholipid complex self-microemulsion particles, disclosed by the invention, is simple, and does not need special high-energy-consumption production equipment in a preparation process; and the obtained product can be used for effectively improving the solubility of resveratrol in water and improving the influences of stomach dispersing and intestinal steatolysis, and is high in biological effective availability.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to a method for preparing resveratrol-phospholipid complex self-microemulsion particles. Background technique [0002] Resveratrol is a non-flavonoid polyphenolic compound containing a stilbene structure, also known as stilbene triphenols. Widely present in natural plants or fruits such as grapes, pine trees, knotweeds, cassia seeds and peanuts, mainly derived from grapes (red wine), knotweeds, peanuts, mulberries and other plants. At least 72 species of plants belonging to 21 families and 31 genera have been found so far. Resveratrol is a phytoalexin produced by many plants when they are subjected to biotic or abiotic stress (such as fungal infection, ultraviolet radiation, etc.). In addition to improving the disease resistance of plants, resveratrol has been found to have a variety of biological activities and pharmacological effects that are beneficial to human health, and has...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/16A61K9/107A61K47/24
CPCA61K9/1652A61K31/05A61K47/24
Inventor 周华锋段明星徐之伟严泽民刘廷强孙春华
Owner KARLIE COSMETICS MFG CO LTD
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