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Graphene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof

A technology of regenerated cellulose and hemostatic materials, applied in the field of hemostatic materials and their preparation, can solve the problems of high price, slow hemostasis speed, inability to use heavy bleeding, etc., and achieve the effect of improving hemostatic performance and reducing hemostatic time

Active Publication Date: 2015-03-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problems that the existing hemostatic materials are expensive, the hemostatic speed is slow, and cannot be used for massive bleeding, and to provide a graphene / oxidized regenerated cellulose composite hemostatic material and its preparation method

Method used

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Effect test

specific Embodiment approach 1

[0019] Embodiment 1: This embodiment is a graphene / oxidized regenerated cellulose composite hemostatic material prepared from redox graphene and oxidized regenerated cellulose filament fabric; the redox graphene and oxidized regenerated fiber The mass ratio of plain filament fabric is (0.05~10):100.

[0020] The advantage of this implementation mode:

[0021] 1. The graphene / oxidized regenerated cellulose composite hemostatic material prepared in this embodiment directly adsorbs nano-graphene on the surface of the oxidized regenerated cellulose filament fabric, which not only improves the hemostatic performance of the material, but also does not damage the material Excellent mechanical strength and bioabsorbability;

[0022] 2. The graphene / oxidized regenerated cellulose composite hemostatic material prepared in this embodiment is used for hemostasis, and the hemostatic time is reduced by 6% to 15%.

[0023] In this embodiment, a graphene / oxidized regenerated cellulose compo...

specific Embodiment approach 2

[0024] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the carboxyl group content in the oxidized regenerated cellulose filament fabric is 16% to 24%. Others are the same as the first embodiment.

specific Embodiment approach 3

[0025] Specific embodiment three: This embodiment is a preparation method of a graphene / oxidized regenerated cellulose composite hemostatic material, which is specifically completed according to the following steps:

[0026] 1. Preparation of graphene solution: add redox graphene to the solvent, and then ultrasonically treat it for 10min-60min under the condition of ultrasonic power of 160W-400W to obtain graphene solution;

[0027] The mass of redox graphene described in step 1 and the volume ratio of solvent are (0.1mg~2mg): 1mL;

[0028] 2. Ultrasonic and freeze-drying: immerse the filament fabric of oxidized regenerated cellulose into the graphene solution, ultrasonically treat it for 10min-60min under the condition of ultrasonic power of 200W-400W, and then use an oscillator to vibrate for 1h-24h. Then the filament fabric of oxidized regenerated cellulose is taken out from the solution of graphene to obtain the filament fabric of oxidized regenerated cellulose after impre...

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Abstract

The invention discloses a graphene / oxidized regenerated cellulose compound hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method of the hemostatic material, and aims at solving the problems that an existing hemostatic material is high in price, and low in bleeding-stopping rate, and cannot be applied to massive haemorrhage. The graphene / oxidized regenerated cellulose compound hemostatic material is prepared from redox graphene and filament fabric of the oxidized regenerated cellulose, wherein the mass ratio of the redox graphene to the filament fabric of the oxidized regenerated cellulose is (0.05-10) to 100. The method comprises the following steps: 1 preparing a graphene solution; and 2 ultrasonically treating and freeze-drying to obtain the graphene / oxidized regenerated cellulose compound hemostatic material. The graphene / oxidized regenerated cellulose compound hemostatic material prepared by the method is used for stopping bleeding; the bleeding-stopping time is reduced by 6%-15%. By adopting the preparation method, the graphene / oxidized regenerated cellulose compound hemostatic material can be obtained.

Description

technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] Various accidents inevitably occur in daily life. During emergency treatment and operation, medical accidents or even death may be caused by massive bleeding. Therefore, local and effective rapid hemostasis of patients is very important, and effective control of bleeding and reducing bleeding time have become important measures to reduce the mortality of patients. Commonly used clinical hemostatic materials such as hemostatic gauze, hemostatic fiber, and hemostatic bandage have limitations in use, such as longer hemostasis time, easy adhesion to the wound and difficult dressing change, and powerlessness to wound infection and suppuration. Rapid hemostasis and functional hemostasis will be the development direction of hemostatic drugs in the future. [0003] Commonly used absorbable hemostatic materials include fibrin glue, gelatin sponge, ox...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 吴亚东黄玉东贺金梅王芳
Owner HARBIN INST OF TECH
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