Polypeptide with immunomodulatory effects

A vaccine and amino acid technology, applied in blood/immune system cells, peptides, protozoan antigen components, etc., can solve the problems of blank bursa active peptide, superficial cognition of bursa active peptide, etc., and achieve good effect and immunity. The effect of very weak originality and simple structure
CN104402971AInactive Publication Date: 2015-03-11QINGDAO AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO AGRI UNIV
Publication Date
2015-03-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention aims to provide polypeptide with immunomodulatory effects, namely undecapeptide which has immunomodulatory effects and is separated from bursa of Fabricius. The amino acid sequence of the polypeptide is SEQ ID NO:1. The bursa of Fabricius undecapeptide separated from a bursa of Fabricius extract product has a simple structure, has no toxic or side effect, and has poor immunogenicity. The polypeptide can be obtained by separation and extraction from bursa of Fabricius and also can be obtained by chemical synthesis. The polypeptide has low cost and can be put into mass production. The polypeptide has an induction effect on antibody production, and also can regulate production of cytokines and proliferation of lymphocyte and promote cellular immune response. In addition, the polypeptide also regulates differentiation of B cell in a dose-dependent mode. The polypeptide has a wide application prospect, taking an application of the polypeptide in the aspects of immunomodulation, treatment and the like for example.
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Description

Technical field

[0001] The invention belongs to the technical field of functional protein / polypeptide screening, and specifically relates to a polypeptide with immunomodulatory effect. Background technique

[0002] Bursa of Fabricius (BF) is a less obvious cyst-like structure attached to the dorsal anal area of ​​the cloaca of birds. The Bursa of Fabricus (BF) was first discovered in 1621 by the Italian anatomist Hieronymus Fabricius, hence the name. Initially, Fabrizius speculated that the hollow structure of the bursa of Fabricius might be used as a container for storing semen. However, this is not the case. For hundreds of years, the function of the bursa of Fabricius has plagued many researchers. Because the bursa degenerates with sexual maturity, and its size is negatively related to the testis and adrenal glands, some researchers speculate that BF must be some kind of endocrine or lymph gland related to growth and sexual development. As early as 1956, Glick and others ac...

Claims

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