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Reduning injection and preparation method thereof

A technology of injection and Reduning, applied in antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as purple, unsteady gait, body skew, side lying, lethargy, etc.

Inactive Publication Date: 2015-03-18
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After investigation, most of the solubilizers of Reduning injection currently available on the market are polysorbate 80 (Tween-80), and related pharmacological studies have found that after intravenous injection of 2% Tween-80 into guinea pigs with 1ml / guinea pigs, the body is skewed, Drowsiness and other obvious symptoms, 5% Tween-80 guinea pigs all had very obvious symptoms such as purple ears, unsteady gait, body tilt, side lying, lethargy; Beagle dogs were slowly injected with Tween-80, and the dose was reduced to 0.02 When % Tween-80 is given at 4ml / volume, the animals will still have obvious allergic symptoms (Sun Li, Liu Xiaomeng, etc., J Toxicol August 2007 Vo1.21 No.4), and other literatures also prove that Tween -80 is the main cause of adverse reactions (anaphylaxis) during its clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1 Reduning injection is prepared from 1250g Artemisia annua, 750g Honeysuckle, 600g Gardenia, 2.0ml HS-15, 0.5g sodium bisulfite and water for injection.

[0008] Example 1 Take 750g of honeysuckle, add water to extract twice, 90°C, 1 hour each time, add 15 times and 10 times of water respectively, and store the extract separately. Distill for 6 hours to extract the volatile oil, separate the volatile oil, extract the honeysuckle extract and Artemisia annua extract, filter, concentrate under reduced pressure to a relative density of 1.10 at 60°C, add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter After that, the filtered solution was concentrated under reduced pressure to a relative density of 1.20 (60°C), adjusted to 2.0 with hydrochloric acid, extracted 10 times with an equal amount of ethyl acetate, and the extract was concentrated under reduced pressure until it had no ethyl acetate smell, poured Take out the concentrated soluti...

Embodiment 2

[0009] Example 2 Reduning injection is prepared from 1250g Artemisia annua, 750g Honeysuckle, 600g Gardenia, 4.0ml HS-15, 0.5g sodium bisulfite and water for injection.

[0010] Example 2 Take 750g of honeysuckle, add water to extract twice, 90°C, 1 hour each time, add 15 times and 10 times of water respectively, and store the extract separately, take 1250g of Artemisia annua and add 4 times the amount of water to moisten thoroughly, steam Distill for 6 hours to extract the volatile oil, separate the volatile oil, extract the honeysuckle extract and Artemisia annua extract, filter, concentrate under reduced pressure to a relative density of 1.10 at 60°C, add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter After that, the filtered solution was concentrated under reduced pressure to a relative density of 1.20 (60°C), adjusted to 2.0 with hydrochloric acid, extracted 10 times with an equal amount of ethyl acetate, and the extract was concentrated unde...

Embodiment 3

[0011] Example 3 Reduning injection is prepared from 1250g Artemisia annua, 750g Honeysuckle, 600g Gardenia, 8.0ml HS-15, 0.5g sodium bisulfite and water for injection.

[0012] Example 3 Take 750g of honeysuckle, add water to extract twice, 90°C, 1 hour each time, add 15 times and 10 times of water respectively, and store the extract separately, take 1250g of Artemisia annua and add 4 times the amount of water to moisten it thoroughly, steam Distill for 6 hours to extract the volatile oil, separate the volatile oil, extract the honeysuckle extract and Artemisia annua extract, filter, concentrate under reduced pressure to a relative density of 1.10 at 60°C, add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter After that, the filtered solution was concentrated under reduced pressure to a relative density of 1.20 (60°C), adjusted to 2.0 with hydrochloric acid, extracted 10 times with an equal amount of ethyl acetate, and the extract was concentrated u...

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PUM

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Abstract

The invention discloses a Reduning injection and a preparation method thereof. The Reduning injection comprises herba artemisiae annuae, honeysuckle, fructus gardenia, HS-15, sodium hydrogen sulfite and injection water. When a traditional Chinese medicine composition is prepared, the different components are subjected to distillation, decoction and ethanol extraction so as to take effects of effective ingredients. The preparation method of the Reduning injection comprises the steps of firstly preparing honeysuckle, herba artemisiae annuae dry paste powder and fructus gardenia dry paste powder, and adding HS-15, sodium hydrogen sulfite and injection water according to the procedure of the preparation so as to prepare the Reduning injection. Compared with commercially available Reduning injections, the Reduning injection has the prominent advantages that by utilizing new prescription and process, the prepared product meets pharmacopeia standards, and untoward effects caused by the Reduning injection are obviously reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a reduning injection and a preparation method thereof. Background technique [0002] Reduning Injection consists of Artemisia annua, Honeysuckle and Gardenia. Artemisia annua relieves exterior heat, aromatizes dampness, and has antipyretic, antiviral, endotoxin-inhibiting, and cellular immunity-promoting effects. Honeysuckle can not only clear away heat and detoxify, but also dispel wind-heat. Gardenia can clear away heat and dampness, relieve fire and trouble, cool blood and detoxify, and both have anti-infection and anti-pathogenic microorganism effects. Reduning injection can directly inhibit and kill rotavirus, improve fever symptoms in children, and improve the body's immunity; at the same time, it can promote the regeneration of damaged small intestinal epithelial cells and mucosal repair, relax smooth muscle, reduce intestinal peristalsis, and inhibit...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K47/34A61K9/08A61P31/12A61P11/00A61P31/00A61P31/16A61P31/22A61P31/14A61P1/12A61P1/04
CPCA61K36/282A61K9/0019A61K9/08A61K36/355A61K36/744A61K47/14A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 张浩金红娣陈程梁慧容
Owner CHENGDU LIST PHARMA
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