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Enteric-coated gelatine empty capsules and preparation method thereof

A technology of hollow capsules and enteric-coated gelatin, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of waste of resources, air pollution, capsule shell residue, etc., to improve costs and facilitate printing , the effect of residual reduction

Active Publication Date: 2015-03-25
SHAOXING KANGKE CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the enteric coating materials resistant to gastric acid are CAP or acrylic resin, and ethanol and acetone must be used as solvents during coating. The solvents evaporate during the molding process. On the one hand, it wastes resources, increases costs, and pollutes the air. remnants of the capsule

Method used

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  • Enteric-coated gelatine empty capsules and preparation method thereof
  • Enteric-coated gelatine empty capsules and preparation method thereof
  • Enteric-coated gelatine empty capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of enteric-coated gelatin hollow capsule embodiment 1 of the present invention comprises the following components, and each component is respectively according to parts by weight:

[0025]

[0026] The preparation method of this enteric-coated gelatin hollow capsule is as follows: add gelatin and water into the reaction kettle, steam for 30-40 minutes, control the temperature at 20-30°C, raise the temperature to 70-85°C, stir well, and slowly add Sodium lauryl sulfate, continue to stir for 25-40 minutes, add sodium alginate, continue to stir evenly, and let it stand for 2-3 hours to react; then send it to the capsule production line for dipping and molding to obtain gelatin hollow capsule material; The mixture of n-butyl acetate and n-butyl acetate is coated on the surface of the obtained gelatin hollow capsule material, stirred vigorously, and then dried. The drying temperature is 60-80°C, and the drying time is 0.5-2h. During the drying process, After being ...

Embodiment 2

[0027] A kind of enteric-coated gelatin hollow capsule embodiment 2 of the present invention comprises the following components, and each component is respectively according to parts by weight:

[0028]

[0029]

[0030] The preparation method of this kind of enteric-coated gelatin hollow capsule is the same as that of Example 1.

Embodiment 3

[0031] A kind of enteric-coated gelatin hollow capsule embodiment 3 of the present invention comprises the following components, and each component is respectively according to parts by weight:

[0032]

[0033] The preparation method of this kind of enteric-coated gelatin hollow capsule is the same as that of Example 1.

[0034] The enteric-coated gelatin hollow capsule comparative example in the prior art comprises the following components, and each component is respectively according to parts by weight:

[0035]

[0036] The preparation method of this kind of enteric-coated gelatin hollow capsule is as follows: Stir the gelatin and water evenly, heat to 70-75°C, then add sodium lauryl sulfate, stir evenly, let it stand for 4-5 hours, and then send it to the capsule production line Carry out glue dipping and molding; then soak in the mixture of acrylic resin, acetone and colorant, and then dry at a temperature of 30°C for 3 to 4 hours, and finally solidify, cool and cu...

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Abstract

The invention discloses enteric-coated gelatine empty capsules. The enteric-coated gelatine empty capsules comprise the following components in parts by weight: 100 parts by weight of gelatine, 3-8 parts by weight of water, 8-15 parts by weight of sodium alginate, 8-15 parts by weight of acrylic resin, 20-45 parts by weight of n-butyl acetate, 5-25 parts by weight of sodium lauryl sulphate and 0-8 parts by weight of colorant. The invention further discloses a preparation method of the enteric-coated gelatine empty capsules. The preparation method disclosed by the invention is capable of effectively solving the technical problems of solvent evaporation during a forming process, resource waste, cost increase and air pollution, thus the capsule shell performance of the produced capsules is more excellent, and the pass percent of finished products is greatly increased.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical excipients, relates to an enteric-coated gelatin hollow capsule, and also relates to a preparation method of the enteric-coated gelatin hollow capsule. Background technique [0002] Enteric-coated hollow capsule, also known as capsule shell, means that the capsule shell is insoluble in gastric juice, but can disintegrate or dissolve in intestinal juice to release the drug in the capsule. The capsule shell is also the main auxiliary material for processing pharmaceutical capsule preparations. Currently used enteric-coated empty capsules are processed and shaped by gelatin and coated with an anti-gastric acid enteric coating material. The gelatin is firstly soaked in purified water, swollen, and then gelatinized, and then sent to the capsule production line to be dipped in glue, dried and solidified to obtain gelatin hollow capsule material, and then enteric-coated on the surface of the gelat...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/14A61K47/32A61K47/42
Inventor 俞愈王孟军俞三愈
Owner SHAOXING KANGKE CAPSULE
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