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Medicament composition for treating osteoarthrosis and application of medicament composition

A technology for osteoarthritis and a composition, applied in the field of traditional Chinese medicine preparations, can solve problems such as adverse reactions to liver damage, achieve good medicinal value and market prospects, and reduce liver toxicity and side effects.

Active Publication Date: 2015-03-25
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that the medicines for treating osteoarthritis in the prior art have certain adverse reactions of liver damage, and then develop a drug combination with lower liver damage and effective treatment of osteoarthrosis thing

Method used

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  • Medicament composition for treating osteoarthrosis and application of medicament composition
  • Medicament composition for treating osteoarthrosis and application of medicament composition
  • Medicament composition for treating osteoarthrosis and application of medicament composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0238] [Prescription] 576.8 grams of Goji, 346.1 grams of Epimedium, 346.1 grams of Duhuo, 462.0 grams of Rhizoma Drynariae, 576.8 grams of Dipsacus, 576.8 grams of Sangji, 346.1 grams of Spatholobus, 1384.2 grams of Rehmannia glutinosa, 346.1 grams of Muxiang, 346.1 grams of frankincense, 346.1 grams of myrrh, and 346.1 grams of psoralen.

[0239] [Preparation method] Mix the frankincense and myrrh according to the selected weight, add 10 times the amount of water to carry out steam distillation and extraction for 12 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is Add excipients at a ratio of 1:10:20:1, grind for 20 minutes for inclusion, dry and pulverize within 50°C, pass through a 120-mesh sieve, and make volatile oil inclusion compound for later use;

[0240] Take the psoralen according to the selected weight, add 8 times the amount of water to extract twice, 1 hour each time, discard the water extract, c...

Embodiment 2

[0243] [Prescription] 290 grams of dog ridge, 520 grams of epimedium, 154 grams of solitary, 692 grams of rhizoma drynaria, 290 grams of diapsacus, 864 grams of mulberry root, 154 grams of milletus, 2076 grams of Rehmannia glutinosa, 154 grams of woody fragrance, 520 grams of frankincense, 154 grams of myrrh and 520 grams of psoralen.

[0244] [Preparation method] Mix the frankincense and myrrh according to the selected weight, add 8 times the amount of water for steam distillation and extraction for 15 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is Add auxiliary materials in a ratio of 1:8:24:1, grind for 20 minutes for inclusion, dry and pulverize within 50°C, and make volatile oil inclusion compound for later use;

[0245] Take the psoralen according to the selected weight, add 6 times the amount of water to extract 3 times, 0.5 hours each time, discard the water extract, collect the dregs, dry to obtain t...

Embodiment 3

[0248] [Prescription] 864 grams of dog ridge, 154 grams of epimedium, 520 grams of solitary, 224 grams of drynaria, 864 grams of diapsac, 290 grams of mulberry, 520 grams of milletus, 692 grams of rehmannia, 520 grams of woody, 154 grams of frankincense, 520 grams of myrrh and 154 grams of psoralen.

[0249] [Preparation method] Mix the frankincense and myrrh according to the selected weight, add 12 times the amount of water for steam distillation and extraction for 8 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is Add auxiliary materials in a ratio of 1:12:16:2, grind for 20 minutes for inclusion, dry and pulverize within 50°C, and make volatile oil inclusion compound for later use;

[0250] Take the psoralen according to the selected weight, add 10 times the amount of water to extract once for 0.5 hours, discard the water extract, collect the dregs, dry to obtain the processed psoralen, and set aside;

[0251...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations and in particular relates to a medicament composition for treating osteoarthrosis. The medicament composition is prepared from the following medicinal raw materials including Asian tree fern rhizome, herba epimedii, pubescent angelica roots, drynaria rhizome, radix dipsaci, loranthus parasiticus, caulis spatholobi, prepared radix rehmanniae, radix aucklandiae, frankincense volatile oil, myrrh volatile oil and processed products of fructus psoraleae. The medicament composition is capable of effectively treating osteoarthritis and lumbar muscle strain caused by deficiency of liver and kidney, qi stagnation, blood stasis and obstructed channels and collateral and also effectively weakening hepatotoxic side effects of original products and has good clinical therapeutic efficacy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for treating osteoarthritis and its application. Background technique [0002] Osteoarthritis (OA) is a common chronic joint disease, the main lesion is the degeneration of articular cartilage and secondary bone hyperplasia. Degenerative osteoarthropathy refers to a series of degenerative lesions in the human body, such as joint pain, stiffness, and limited mobility. It is a comprehensive disease. Its incidence rate is only second to heart disease in the crowd over 50 years old, and the incidence rate in the crowd over 65 years old is as high as 60-90%, especially brings great pain and inconvenience to the life of middle-aged and elderly people. [0003] Lumbar muscle strain is also the most common type of pain in low back pain, and is often used as a general term for chronic low back pain without organic changes. ...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P19/02
CPCA61K9/0053A61K36/11A61K36/126A61K36/185A61K36/232A61K36/285A61K36/296A61K36/324A61K36/328A61K36/486A61K36/487A61K36/804A61K2236/331A61K2300/00
Inventor 代志徐冰王勇刘志刚周昆王跃飞李琼娅马鹏岗王静赵枫林李霞
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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