Allicin solution and production method thereof
A technology for allicin and a production method, which is applied in the directions of pharmaceutical formulations, drug delivery, and devices for making drugs into special physical or taking forms, can solve the problems of low content of active ingredients, difficulty in extracting allicin, and the like, and achieves Excellent quality, simple and efficient production process, and the effect of maintaining physical properties
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Embodiment 1
[0042]Embodiment 1, this allicin solution obtains by following preparation method: the first step, prepares the deoxygenated water for injection that oxygen content is less than 2ppm; The second step, according to deoxygenated water for injection: allinase: the mass ratio of alliin is Mix deoxygenated water for injection, allinase and alliin at a ratio of 57:1:1 to 57:3:1 at a temperature of 25°C, control the pH of the solution to 6.5 to 7.0, and stir at a rate of 30rmp to 100rmp Stir at low temperature until the cleavage reaction is completed to obtain the reaction solution, then lower the temperature of the reaction solution to 0°C to 4°C, use argon for positive pressure protection during this step and always isolate it from the air; in the third step, first pass the reaction solution through The microfiltration device removes visible precipitates in the reaction solution, and then the reaction solution is passed through the ultrafiltration device to remove macromolecular sub...
Embodiment 2
[0043] Embodiment 2, as the preference of implementing 1, allicin solution is further processed to obtain allicin injection injection: first measure the concentration of allicin solution, and then add allicin to the concentration of allicin injection according to the concentration of required allicin injection Add a required amount of deoxygenated water for injection into the solution, mix well to obtain allicin injection, control the pH value of the allicin solution to 6.5 to 7.0, and send the allicin injection into the injection filling device and put it into the pre- The allicin injection was obtained in the syringe needle. During the operation, the temperature of the allicin solution and the allicin injection was kept at 0°C to 4°C, and the positive pressure protection with argon was always used during the operation. Keep away from air.
Embodiment 3
[0044] Embodiment 3, as the preference of implementation 1, the allicin solution is further processed to obtain the allicin reference substance: the allicin solution is repeatedly extracted with ether, after the extraction is completed, the ether layer is taken for molecular distillation, and the molecular distillation conditions : Control injection flow rate from 2 ml / min to 10 ml / min, scraper speed from 40 r / min to 70 r / min, cooling temperature from 5°C to -15°C, vacuum degree from 0.08 torr to 1 torr, molecular After the distillation is completed, a greasy light yellow allicin viscous semi-solid is obtained, which is the allicin standard reference substance.
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