Pharmaceutical composition derived from eucommia ulmoides and use of pharmaceutical composition

A technology of composition and medicine, which is applied in the field of pharmaceutical composition derived from Eucommia, can solve the problems of large dosage and long time, and achieve the effect of obvious curative effect, better and more significant effect, and great clinical development value

Active Publication Date: 2015-04-08
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these several medication methods require a large amount of medi

Method used

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  • Pharmaceutical composition derived from eucommia ulmoides and use of pharmaceutical composition
  • Pharmaceutical composition derived from eucommia ulmoides and use of pharmaceutical composition
  • Pharmaceutical composition derived from eucommia ulmoides and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Effect of pharmaceutical composition on osteoporosis caused by ovariectomy (OVX) in rats

[0022] Female SD rats, about 200g, were randomly divided into groups (12 in each group). The castrated rats were operated as follows, anesthetized by ether inhalation, and under strict aseptic operation, a median incision was made on the posterior side of the lumbar spine, and the paravertebral muscles were bluntly separated. tissue, cut the peritoneum, and enter the abdominal cavity. After complete removal of both ovaries, penicillin was sprinkled, the skin was sutured, and the wound was disinfected. The operation of the sham operation group was the same as above, only a little fat tissue around the ovary was removed, and the ovaries were not removed. After the model was established, the rats were given intragastric administration. The dosage of each administration group was 30 mg / kg per day for 6 weeks. , the component weight ratio of each administration group is as f...

Embodiment 2

[0039] Example 2 Effect of pharmaceutical composition on rat osteoporosis caused by retinoic acid

[0040] Get female SD rats, about 200g, and randomly divide them into groups (12 in each group). Rats in the model group and each administration group are given 80 mg / kg of retinoic acid by intragastric administration every day for 14 days. After successful modeling, start Rats were administered intragastrically, and the dosage of each administration group was 30 mg / kg per day for 4 weeks. The weight ratio of the components of each administration group was the same as that in Example 1.

[0041] The specific results are as follows:

[0042] group

[0043] Dosing group 3

[0044] ▲▲P<0.01 compared with the sham operation group, **P<0.01 compared with the model group

Embodiment 3

[0045] Example 3 Effect of pharmaceutical composition on mouse embryonic osteoblast MC3T3-E1 proliferation and mineralization

[0046] Take the MC3T3-E1 cells grown in the logarithmic phase, and dilute them with MEM complete medium to 2×10 4 cells / ml, 1ml per well was spread into a 24-well plate, cultivated in an incubator for 3 days, removed the complete medium, added serum-free medium containing the pharmaceutical composition to a final drug concentration of 30 μg / L, and cultivated for 48 hours. The model group was without Serum medium, the cell proliferation was measured by MTT method, and the cell mineralization function (bone nodule formation rate) was measured by Alizarin red method. The specific results are as follows:

[0047] group

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines and specifically relates to a pharmaceutical composition derived from eucommia ulmoides and a use of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in percentage by weight: 5-60% of pinoresinol diglucoside, 5-60% of eucommiae ulmoides glycoside, 5-60% of ferulic acid and 5-60% of betulin, preferably, 30-55% of pinoresinol diglucoside, 10-30% of eucommiae ulmoides glycoside, 10-30% of ferulic acid and 20-40% of betulin. After years of experiment research and clinical practice, a pharmaceutical composition having obvious curative effect on osteoporosis is screened from the active compounds in the eucommia ulmoides. Besides, the osteoporosis treatment effect of the composition is improved to be better and more remarkable by virtue of reasonable optimization of matching by weight in combination with the modern science and technology; as a result, the pharmaceutical composition derived from the eucommia ulmoides has a tremendous clinical development value.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a medicinal composition derived from Eucommia ulmoides and its application. Background technique [0002] Osteoporosis (ostcoporosis, OP) is a systemic bone disease characterized by decreased bone mass, degeneration of bone microstructure, decreased bone strength, and increased fragility leading to increased susceptibility to fracture. Most of them are middle-aged and elderly people, the incidence rate is about 7% worldwide, and the ratio of male to female is 1:4. There are currently about 97 million OP patients in China, and women account for two-thirds, ranking first among geriatric diseases. It is known as a "quiet" epidemic. [0003] From a cytological point of view, the imbalance between osteoblasts (OB) and osteoclasts (OC) is one of the important causes of osteoporosis. Due to the decrease of OB predominance and the increase of OC predominance, ins...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P19/10A61K31/7034A61K31/365A61K31/56
CPCA61K31/365A61K31/56A61K31/7034A61K31/7048A61K2300/00
Inventor 肖军平吴永忠康兴东陈梁周朝忠
Owner JIANGXI POZIN PHARMA
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