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Solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride

A technology of metformin hydrochloride and colesevelam hydrochloride, which is applied in the field of pharmaceutical preparations, can solve undisclosed problems, and achieve the effects of improving compliance, reducing the number of medications, and lasting effects

Inactive Publication Date: 2015-04-08
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the medicines about metformin hydrochloride disclosed at home and abroad involve a variety of formulations and preparations, such as metformin rosiglitazone, metformin repaglinide, metformin glyburide, etc., but never disclosed about colesevelam hydrochloride. Combination drug formulation with metformin hydrochloride

Method used

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  • Solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride
  • Solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride
  • Solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride

Examples

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Effect test

Embodiment 1

[0027] Embodiment 1: the solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride is a double-layer tablet, which includes an immediate-release layer and a sustained-release layer; described solid oral preparation is composed of the following raw materials in parts by weight: immediate release Layer: colesevelam hydrochloride: 500, immediate release layer excipients: croscarmellose sodium: 100; sustained release layer: metformin hydrochloride: 100, sustained release layer excipients: hypromellose K series: 20, PVPK Series: 2, magnesium stearate: 1.

[0028] The preparation method of above-mentioned solid oral preparation, it comprises the following steps:

[0029] (1) Preparation of the immediate-release layer: pass colesevelam hydrochloride through a 100-mesh sieve, pass through an 80-mesh sieve for the auxiliary materials of the immediate-release layer, and directly compress the powder into tablets for one-time compression molding;

[0030] (2...

Embodiment 2

[0032] Embodiment 2: the solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride is a double-layer tablet, which includes an immediate release layer and a sustained release layer; the solid oral preparation is composed of the following raw materials in parts by weight: immediate release Layer: colesevelam hydrochloride: 1000, immediate release layer excipients: starch: 100, direct compression lactose: 200, croscarmellose sodium: 30, croscarmellose sodium: 30, carboxymethyl starch sodium : 25, Hydroxypropyl Cellulose: 25, Magnesium Stearate: 10; Sustained Release Layer: Metformin Hydrochloride: 1000, Sustained Release Layer Excipients: Hypromellose K Series: 400, PVPK Series: 20, Stearic Acid Magnesium: 5.

[0033] The preparation method of above-mentioned solid oral preparation, it comprises the following steps:

[0034] (1) Preparation of the immediate-release layer: pass colesevelam hydrochloride through a 100-mesh sieve, pass through an 80-m...

Embodiment 3

[0037] Embodiment 3: the solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride is a double-layer tablet, which includes an immediate release layer and a sustained release layer; the solid oral preparation is made up of the following raw materials in parts by weight: immediate release Layer: colesevelam hydrochloride: 600, immediate release layer excipients: lactose monohydrate: 100, croscarmellose sodium: 80; sustained release layer: metformin hydrochloride: 300, sustained release layer excipients: hypromellose Prime K series: 100, PVPK series: 45, magnesium stearate: 5.

[0038] The preparation method of above-mentioned solid oral preparation, it comprises the following steps:

[0039] (1) Preparation of the immediate-release layer: pass colesevelam hydrochloride through a 100-mesh sieve, pass through an 80-mesh sieve for the auxiliary materials of the immediate-release layer, and directly compress the powder into tablets for one-time compres...

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Abstract

The invention discloses a solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride. The solid oral preparation containing the metformin hydrochloride and colesevelam hydrochloride is a double-layer tablet and comprises a quick release layer and a sustained release layer, wherein the quick release layer comprises 500-1000 parts by weight of colesevelam hydrochloride and a quick release layer auxiliary material, and weight ratio of colesevelam hydrochloride to the quick release layer auxiliary material is 1:(0.2-0.5); and the sustained release layer comprises 100-1000 parts by weight of metformin hydrochloride and a sustained release layer auxiliary material, and weight ratio of metformin hydrochloride to the sustained release layer auxiliary material is 1:(0.2-0.5). The invention provides a medicine which has a synergistic effect of lowering blood glucose and is simple in composition, convenient in administration, lasting in effect and stable in curative effect. The invention also discloses a preparation method of a solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride, in particular to a solid oral preparation containing metformin hydrochloride and colesevelam hydrochloride and a preparation method thereof. Background technique [0002] Metformin hydrochloride belongs to the biguanide hypoglycemic drugs. Biguanides are internationally recognized as safe and effective oral hypoglycemic drugs, and are currently routinely used in adults with type 2 diabetes. Increase, aerobic metabolism remains unchanged, it concentrates on the intestinal wall, inhibits the absorption of glucose in the intestine, inhibits gluconeogenesis, inhibits the release of glucagon or inhibits the effect of insulin antagonists, and increases insulin sensitivity. Metformin hydrochloride has a hypoglycemic effect on diabetics with normal or lost pancreatic islet functi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K9/24A61P3/10A61P3/06A61P3/00A61K31/155
CPCA61K31/785A61K9/0053A61K9/205A61K9/2054A61K9/2059A61K9/209A61K31/155A61K2300/00
Inventor 沈桦朱德其
Owner CHENGDU HENGRUI PHARMA
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