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Anti-infection bone cement and preparation method thereof

A bone cement and anti-infection technology, applied in medical science, prosthesis, etc., to achieve the effect of promoting bone density increase, avoiding antibiotic resistance, and having great clinical application value

Active Publication Date: 2015-04-15
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irrational use of antibiotics, drug-resistant bacteria are gradually increasing in clinical practice (such as drug-resistant Staphylococcus aureus MRSA, drug-resistant Staphylococcus epidermidis MRSE, etc.), it is difficult to apply conventional implanted antibiotic bone cement, so the development of new There is an urgent clinical need for anti-infective implants and fixation materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Mix Mg-Ag alloy particles with a particle size of 3mm (magnesium content is 99wt%) and PMMA powder at a weight ratio of 20:100, and then add bone cement monomer at a liquid / powder ratio of 1.5ml / 2mg. Get infection-resistant bone cement.

[0022] biosecurity

[0023] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the anti-infection bone cement provided by the invention has no obvious cytotoxicity and blood coagulation to osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0024] Mechanical strength

[0025] Bone cement compressive strength and modulus: In this experiment, 5 sets of bone cement test strips were measured for each group. The mechanical experiment was carried out at (23±1)°C. The cylinder of the prepared anti-infection bone cement was placed in the testing machine, and the testing machine was started to draw ...

Embodiment 2

[0032] Mix Mg-Cu alloy particles with a diameter of 3mm (with a magnesium content of 99.5wt%) and PMMA powder at a weight ratio of 25:100, and then add bone cement monomer at a liquid / powder ratio of 1.5ml / 2mg , to obtain anti-infective bone cement.

[0033] biosecurity

[0034] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the anti-infection bone cement provided by the invention has no obvious cytotoxicity and blood coagulation to osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0035] Mechanical strength

[0036] Bone cement compressive strength and modulus: In this experiment, 5 sets of bone cement test strips were measured for each group. The mechanical experiment was carried out at (23±1)°C. The cylinder of the prepared anti-infection bone cement was placed in the testing machine, and the testing machine was started to...

Embodiment 3

[0043]Pure magnesium particles with a particle size of 5 mm and PMMA powder were uniformly mixed at a weight ratio of 49:100, and then bone cement monomer was added at a liquid / powder ratio of 1.5ml / 2mg to obtain an anti-infective bone cement.

[0044] biosecurity

[0045] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the anti-infection bone cement provided by the invention has no obvious cytotoxicity and blood coagulation to osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0046] Mechanical strength

[0047] Bone cement compressive strength and modulus: In this experiment, 5 sets of bone cement test strips were measured for each group. The mechanical experiment was carried out at (23±1)°C. The cylinder of the prepared anti-infection bone cement was placed in the testing machine, and the testing machine was started to draw a...

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Abstract

The present invention provides an anti-infection bone cement, which comprises magnesium-based metal particles, a bone cement matrix and a bone cement monomer, wherein a weight ratio of the magnesium-based metal particles to the bone cement matrix is (1-60):100, and the ratio of the volume of the bone cement monomer to the total mass of the magnesium-based metal particles and the bone cement matrix is (0.5-3 mL):(1-5 mg). According to the anti-infection bone cement of the present invention, the bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used PMMA antibiotic bead chain so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement is achieved while the generation of the antibiotic resistance is avoided; the anti-infection bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the anti-infection bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

Description

technical field [0001] The invention relates to the field of biological preparations, in particular to a controllable slow-release anti-infection bone cement with the effect of increasing bone density and a preparation method thereof. Background technique [0002] With the increase of the aging population, the extension of life expectancy and the improvement of the quality of life, total knee and total hip replacement and PVP (PKP) technology for the treatment of osteoporotic spinal compression fractures are increasingly widely used in orthopedic clinics. In these operations, polymethyl methacrylate (PMMA) is the most commonly used implant fixation material, which can achieve immediate and reliable fixation of joint prostheses and fracture ends. But like other implant materials, PMMA will also increase the risk of infection due to bacterial invasion and biofilm formation on its surface. Clinically, after primary total hip and total knee replacement, the incidence of deep in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/54A61L27/58
Inventor 曲新华戴尅戎李扬
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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