Pharmaceutical composition with anti-aging effect

A composition and anti-aging technology, applied in the direction of drug combination, application, anti-toxic agent, etc., can solve the problems of unpublished related effects and undisclosed extracts, etc., and achieve the effect of prolonging life, significant effect, and prolonging life

Active Publication Date: 2015-04-22
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the patent does not disclose the specific substance of its extr

Method used

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  • Pharmaceutical composition with anti-aging effect
  • Pharmaceutical composition with anti-aging effect
  • Pharmaceutical composition with anti-aging effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The acquisition of monomeric compounds

[0035] 5 kg of traditional Chinese medicine Radix Astragali was pulverized, extracted three times with 95% ethanol under reflux, combined the three extracts, concentrated under reduced pressure, and dried in vacuum to obtain 182 g of extract. Suspend the extract with about 10 times the amount of water, and extract with chloroform, ethyl acetate, and n-butanol in sequence. After recovering the solvent, extracts of various fractions were obtained. The chloroform extraction site was subjected to repeated silica gel chromatography, eluted with different proportions of petroleum ether-acetone gradient, and crystallized with acetone to obtain the compound 7,2'-dihydroxy-3',4'-dimethoxyisoflavan, Formononetin, Calycosin. The ethyl acetate extraction part was subjected to repeated normal phase silica gel chromatography with chloroform-methanol gradient elution and reverse phase silica gel chromatography with methanol-water gradient elu...

Embodiment 2

[0046] The anti-aging pharmaceutical composition is formulated from the following monomer compounds in parts by weight (unit: mg)

[0047]

[0048] The pharmaceutical composition of this example significantly prolongs the average lifespan of adult nematodes, and exhibits a dose-dependent effect.

Embodiment 3

[0050] The anti-aging pharmaceutical composition is formulated from the following monomer compounds in parts by weight (unit: mg)

[0051]

[0052] The pharmaceutical composition of this example significantly prolongs the average lifespan of adult nematodes, and exhibits a dose-dependent effect.

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Abstract

The invention relates to a pharmaceutical composition with an anti-aging effect. The pharmaceutical composition is prepared from the following monomer compounds in parts by weight: 12-18 parts of 7,2'-dyhydroxy-3',4'-dimethoxyisofiavanone, 9-14 parts of (6aR, 11aR)-9,10-dimethoxy pterocarpan-3-oxo-beta-D-glucoside, 6-10 parts of formononetin, 7-11 parts of formononetin-7-oxo-beta-D-glucoside, 20-30 parts of calycosin and 20-30 parts of calycosin-7-oxo-beta-D-glucoside. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the effects of significantly prolonging life, can be used for preventing and treating aging-related diseases such as senile dementia, cardiovascular diseases and diabetes, and can be applied to the field of health foods.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anti-aging pharmaceutical composition, which belongs to the field of medicine and health food. Background technique [0002] With the progress of society and the continuous improvement of people's living standards, human beings put forward an urgent requirement for the extension of life span, that is, to try their best to reach the maximum age that a person can live to. In recent years, researchers at home and abroad are trying to explore and find anti-aging drugs and methods. [0003] Data from the World Health Organization show that aging-related diseases have become an important factor in human death. Aging-related diseases include malignant tumors and degenerative diseases of various tissues and organs such as heart failure, atherosclerosis, abdominal aortic aneurysm, diabetes, cardiac hypertrophy, osteoporosis, tissue / organ fibrosis, Alzheimer's disease, Parkinson's syndr...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/28A61P9/00A61P39/00A61P3/10A23L1/30A61K31/353A61K31/352
CPCA23V2002/00A61K31/352A61K31/353A61K31/7048A61K2300/00A23V2200/302A23V2200/322A23V2200/326A23V2200/328A23V2250/2116
Inventor 王红兵陈威
Owner TONGJI UNIV
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