Adsorbent for removing LDL and preparation method thereof

A technology of adsorbent and solvent, which is applied in the field of adsorbent for LDL removal and its preparation, can solve the problems of complex preparation method and low adsorption efficiency, and achieve the effects of simple process, improved adsorption performance and reduced safety problems

Active Publication Date: 2015-04-22
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantages of complex preparation methods and low adsorption efficiency of existing adsorbents, break through the existing adsorbent mode, and provide a novel adsorbent for LDL removal based on porous fibers and its preparation method

Method used

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  • Adsorbent for removing LDL and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 1.5ml of ethanol and 0.5ml of deionized water to 8ml of tetrahydrofuran to obtain a mixed solution with a volume ratio of THF, ethanol and water of 8:1.5:0.5; accurately weigh 1.0mg of polyvinyl butyral, 0.10 of polyglutamic acid mg, sodium chloride 0.1mg, add the above mixed solution in turn while stirring, seal, and stir overnight at 25°C to obtain a clear and transparent spinning solution; inject the spinning solution into a 10ml syringe and connect a No. 5 stainless steel needle (inner diameter 0.5mm) , adjust the output voltage of the high-voltage power supply to 10kv, adjust the flow rate of the syringe pump to 0.8ml / h, and the receiving distance to 15cm, and use a grounded aluminum foil as the receiving device; after spinning, put the fiber membrane and the aluminum foil at the bottom together into a 60 ℃ in a vacuum drying oven, vacuum dry for 4 hours to fully evaporate the solvent; peel off the fiber membrane from the aluminum foil, add deionized water to so...

Embodiment 2

[0042] Add 3.0ml of ethanol and 1.0ml of deionized water to 6.0ml of tetrahydrofuran to obtain a mixed solution with a volume ratio of THF, ethanol and water of 6:3:1; accurately weigh 0.8mg of polyvinyl butyral, polyglutamic acid 0.15mg, sodium chloride 0.2mg, while stirring, add the above-mentioned mixed solution in sequence, seal, and stir overnight at 25°C to obtain a clear and transparent spinning solution; inject the spinning solution into a 10ml syringe, connect a No. 5 stainless steel needle (inner diameter 0.5mm ), adjust the output voltage of the high-voltage power supply to 16kv, adjust the flow rate of the syringe pump to 1.2ml / h, and the receiving distance to 20cm, use a grounded aluminum foil as the receiving device; after spinning, put the fiber membrane together with the aluminum foil at the bottom In a vacuum oven at 60°C, vacuum-dry for 4 hours to fully evaporate the solvent; peel off the fiber membrane from the aluminum foil, soak in deionized water and ultra...

Embodiment 3

[0044] Add 3ml of ethanol and 2ml of deionized water to 5ml of tetrahydrofuran to obtain a mixed solution with a volume ratio of THF, ethanol and water of 5:3:2; accurately weigh 0.6mg of polyvinyl butyral and 0.2mg of polyglutamic acid, Sodium chloride 0.20 mg, while stirring, add the above-mentioned mixed solution successively, seal, and stir overnight at 25 ° C to obtain a clear and transparent spinning solution; inject the spinning solution into a 10ml syringe, connect a No. 6 stainless steel needle (inner diameter 0.6mm), adjust The output voltage of the high-voltage power supply is 20kv, the flow rate of the syringe pump is adjusted to 1.5ml / h, the receiving distance is 25cm, and the grounded aluminum foil is used as the receiving device; after the spinning is completed, put the fiber membrane together with the aluminum foil at the bottom into a vacuum at 60°C In a drying oven, vacuum-dry for 4 hours to fully evaporate the solvent; peel the fiber membrane from the aluminu...

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Abstract

The invention provides an adsorbent for removing LDL. The adsorbent is composed of porous composite fibers and comprises a hydrophilic carrier as an adsorbent base and glutamic acid as a ligand and the porous composite fibers have aperture sizes of 30-80nm. The invention also provides a preparation method of the adsorbent. The preparation method utilizes an electrostatic spinning technology. The porous composite fibers can provide an enough large porous structure and produce carrier adsorption performances. Glutamic acid is a human essential amino acid, has no safety hidden trouble, comprises a pGlu long chain containing a large amount of carboxyl groups, provides abundant binding sites for LDL adsorption, can remove LDL in blood according to an electrostatic bonding principle and greatly improves material adsorption performances by synergism of the ligand and the carriers. The adsorbent is prepared by simple processes under mild conditions, and the molecular chain mixed in the carriers does not shed easily so that ligand shedding-caused safety problems are reduced.

Description

technical field [0001] The invention relates to an adsorbent, in particular to an adsorbent for removing LDL and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases caused by atherosclerosis are the main cause of death in my country and western countries in recent years. Medical research and clinical practice have proved that the abnormal increase of low-density lipoprotein (10w density lipoprotein. ) is the main factor causing atherosclerosis. Therefore, reducing the level of low-density lipoprotein in plasma has become the starting point for the prevention and treatment of cardiovascular diseases, especially for patients with familial hyperlipidemia who are ineffective in diet and drug therapy, because familial hyperlipidemia is a general disease caused by blood lipid disorders. The disease of high cholesterol and low-density lipoprotein is an autosomal dominant genetic disease caused by mutation of the low-density lipo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/34
CPCA61M1/3679B01J20/261B01J20/262B01J20/28038B01J2220/445B01J2220/4812
Inventor 董凡曾静雯
Owner JAFRON BIOMEDICAL
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