Artemisia annua wax oil sodium copper chlorophyllin and preparation method thereof

Abstract

The invention discloses artemisia annua wax oil sodium copper chlorophyllin and a preparation method thereof. Wax oil is heated and dissolved by absolute ethyl alcohol and stands at the low temperature ranging from -15 DEG C to -5 DEG C, and then a chlorophyll ethanol solution is filtered and collected; vitriol is dropwise added to adjust the pH value to range from 2 to 3, heating reflux is carried out for 20 min to 40 min, a 10% to 20% CuSO4 solution with the volume from 1 to 2 is added into the solution, and suspended de-magging chlorophyllin copper paste sediment is separated out of the solution; the paste sediment washed by water is dissolved by acetone, a 5% sodium hydroxide-ethanol solution is added to adjust the pH value to range from 11 to 12, water bath is carried out at the temperature ranging from 50 DEG C to 70 DEG C for 1 h to 2h, and finally the artemisia annua wax oil sodium copper chlorophyllin is obtained after crystallization. The artemisia annua wax oil has abundant chlorophyll and has the development and utilization value. By means of the preparation method, sodium copper chlorophyllin can be efficiently prepared, and the product quality meets the national standard. The artemisia annua wax oil sodium copper chlorophyllin and the preparation method of the artemisia annua wax oil sodium copper chlorophyllin have the industrial development prospect, and are of important significance in improving the artemisia annua wax oil additional value, broadening the artemisia annua industrial way and protecting environment.

Description

technical field [0001] The invention relates to a preparation method of copper chlorophyllin sodium, in particular to a method for preparing copper chlorophyllin sodium from Artemisia annua wax oil. Background technique [0002] Artemisia annua ( Artemisia annua L . ) is an annual herb of the genus Artemisia in the family Asteraceae. It is a traditional Chinese medicine in my country. The value of its active ingredient, artemisinin, in the prevention and treatment of malaria has been recognized and accepted by humans. Artemisia annua wax oil (wax oil) is the initial purification residue of artemisinin extracted from Artemisia annua organic solvent (8# solvent oil). Chemical components such as wax have important development value. At present, the production of 1 ton of artemisinin can produce about 5 tons of wax oil by-products. According to preliminary estimates, about 20 large-scale artemisinin production enterprises in the country produce about 500 tons of wax oil per y...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned technical problems of the difficult development and utilization of Artemisia annua wax oil and heavy environmental pollution, the inventors have finally invented a wax oil based on the analysis of wax oil components and chlorophyll (Wax oil chlorophyll) content after long-term experiments. A method for preparing sodium copper chlorophyllin with Artemisia annua wax oil as the main raw material, the method is simple and efficient, the obtained product is of good quality, and has industrial development prospects