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Application of frankincense extract in preparation of vascular endothelial homeostasis maintaining medicine

A technology of vascular endothelium and extract, which is applied in the field of medicine, can solve the problems of drug absorption and bioavailability reduction, limit clinical application, etc., and achieve the effect of delaying cardiovascular and cerebrovascular diseases, simple preparation process, and delaying development

Inactive Publication Date: 2015-04-29
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because the active ingredients of frankincense extract are water-insoluble, the commonly used clinical dosage forms of frankincense and its compound are pills, capsules, tablets, powders, ointments and other oral or external preparations, and there are no intravenous dosage forms, which makes drug absorption and bioavailability The degree is greatly reduced, which greatly limits the clinical application of the drug

Method used

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  • Application of frankincense extract in preparation of vascular endothelial homeostasis maintaining medicine
  • Application of frankincense extract in preparation of vascular endothelial homeostasis maintaining medicine
  • Application of frankincense extract in preparation of vascular endothelial homeostasis maintaining medicine

Examples

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preparation example Construction

[0014] Preparation of boswellia alcohol extract emulsion: Boswellia extract 10-30%, ethanol 1-5%, lecithin 10-30%, refined soybean oil 5-25%, oleic acid 0.5-6.5%, tocopherol 0.01-1.0% , Add physiological saline for injection to 100%.

[0015] The preparation method of the above-mentioned frankincense extract for injection is: add 1-5% ethanol, 5-25% refined soybean oil, 0.01-1.0% tocopherol and 0.5-6.5% oleic acid to 10-30% frankincense extract, and quickly Stir to make an oil phase; prepare 10-30% lecithin and saline for injection to make a water phase, mix the two phases of oil and water, and stir at a high speed to make colostrum; add saline for injection to 100%, and adjust the pH to 5.0-7.0 , into a high-pressure homogenizer, and repeatedly emulsified until the average particle size of emulsion droplets is ≤0.5 μm; take the above-mentioned emulsion, filter it, fill it with nitrogen gas, and sterilize it.

[0016] The frankincense extract of the present invention can be u...

Embodiment 1

[0019] Take 200 mg of frankincense extract, add 100 μl of absolute ethanol, 200 mg of refined soybean oil, 80 mg of oleic acid, and 1 mg of tocopherol, stir at 50°C at high speed to dissolve evenly, and make an oil phase; dissolve 200 mg of lecithin in an appropriate amount of physiological In the saline, stir at 50°C at a high speed to dissolve it evenly to form a water phase; mix the oil and water two phases at 60°C and stir at a high speed to make colostrum; add physiological saline for injection to 2mL, adjust the pH to 5.0-7.0, and make high pressure milk In a homogenizer, emulsify repeatedly until the average particle size of emulsion droplets is ≤0.5μm. Take the above-mentioned emulsion, filter it, fill it with nitrogen gas, and sterilize it.

Embodiment 2

[0021] The above-mentioned frankincense emulsion was placed at room temperature, high temperature and light, and the properties, pH value, insoluble particles and visible foreign matter were investigated on day 0, day 5 and day 10 respectively. The results are shown in Table 1: the formulation is stable.

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Abstract

The invention discloses an application of a frankincense extract in preparation of a vascular endothelial homeostasis maintaining medicine. The frankincense extract can be used for preparing the medicine capable of preventing damage and malfunction of a vascular endothelial cell structure due to obesity, ill living habits such as long-term smoking, drinking and the like as well as chronic stress, can be used for Preparing medicine for treating vessel wall thickening and lumen stenosis type cardiovascular diseases caused by vascular endothelial injury and matrix precipitation, and has the advantages of high activity, small toxic and side effects and low cost.

Description

technical field [0001] The invention relates to the application of frankincense extract in the preparation of medicines for preventing and treating vascular endothelial homeostasis, and belongs to the technical field of medicine. Background technique [0002] Vascular endothelial cells are a layer of monocytes between the blood flow and the vascular wall tissue, which can secrete a series of vasoactive substances such as NO, PGI2, ET-1 through secretion, endocrine, and paracrine pathways to regulate vascular tension Antithrombotic, anti-thrombosis, inhibition of smooth muscle cell proliferation and vascular wall inflammatory response and other functions. The destruction of vascular endothelial homeostasis is closely related to living environment and lifestyle. Obesity, smoking, bad living habits and chronic stress can all lead to damage to the vascular endothelium. Changes in the structure and function of endothelial cells are the common pathological basis of various cardi...

Claims

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Application Information

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IPC IPC(8): A61K36/324A61P9/00A61P3/04A61P9/12A61P3/06A61P9/10A61P3/10A61P7/00
Inventor 文爱东李玉文张一恺王明明丁一陈敏纯
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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