Preparation method for synthesizing indoline through idodine catalysis of amide compound

Abstract

The invention provides an environment-friendly catalytic synthesis method for synthesizing indoline through catalysis of an amide compound. The method comprises the following steps: using the easily obtained amide compound as a raw material, using iodine as a catalyst, adding alkali, using peroxide as an oxidant, and in a polar solvent, performing reflux reaction at 80-160 DEG C, so as to obtain a corresponding indoline compound. The method is low in cost and free of heavy metal pollution; by the method, requirements on environment-friendly chemistry and sustainable development are met; a catalytic effect on a complicated substrate is relatively good, so that diversity of products is greatly enriched; the method further has the main advantages as follows: by the method, an experiment is simple and convenient, the yield is high, the applicability is wide, high efficiency, economy and environment friendliness are realized in a true sense, and the practicability is relatively high.

Description

【Technical field】 [0001] The invention belongs to the field of catalytic organic synthesis, and specifically relates to a non-metallic iodine element as a catalyst, using amide compounds as raw materials, peroxides as oxidants, and alkalis as additives to undergo self-coupling and ring-closing reactions in organic solvents , a green catalytic synthesis method to obtain indoline derivatives in high yield. 【Background technique】 [0002] Nitrogen-containing organic compounds are an important part of organic chemistry research, and are important constituent units of some drugs; most of them contain biological activity and are commonly found in drugs. The research on benzonitrogen-containing heterocyclic compounds has always been an area of ​​interest to organic chemists. Therefore, methods for synthesizing these compounds conveniently and efficiently have attracted people's attention. [0003] Indoline is an important constituent unit of some drugs. It is a hot spot in this fi...

AI Technical Summary

Problems solved by technology

Among them, the hydrogenation reduction method requires high temperature and high pressure, high requirements on the reaction device, and easily produces by-products; the reduction method of borohydride, the reducing agent is more expensive, the cost is higher, and it is difficult to realize industrial production; the metal-acid reduction system will produce A large amount of waste acid water also uses mercury, which is highly toxic and pollutes the environment

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