Brain tumor targeted drug delivery system and preparation method thereof
A drug delivery system, a technology for brain tumors, applied in antitumor drugs, pharmaceutical formulations, drug combinations, etc., can solve brain diseases epilepsy, schizophrenia difficult to achieve effective treatment, lack of tumor tissue selectivity, dose-dependent acute Toxicity and other issues, to achieve the effect of improving brain entry efficiency, good solubilization effect, and improved uptake and transport rates
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Embodiment 1
[0050] Dissolve adriamycin in absolute ethanol, dissolve the glucose-modified amphiphilic chitosan derivative, which is the drug delivery carrier, in water, and slowly add the adriamycin solution to the drug delivery carrier solution under rapid stirring. After the solution is mixed, ultrasonic for 0.5h, ultrasonic power 360w, ultrasonic frequency 28KHz, deionized water dialysis, 0.22μm microporous filter membrane to filter out unencapsulated doxorubicin, then glucose-modified brain tumor targeting nanomicelle delivery system.
[0051] The concentration of the doxorubicin in absolute ethanol is 10 mg / mL; the concentration of the drug delivery vehicle in water is 15 mg / mL; the weight ratio of the doxorubicin to the drug delivery vehicle is 1:5;
[0052] The weight ratio of doxorubicin to drug delivery carrier in the prepared drug delivery system is 1:6;
[0053] The drug delivery carrier is synthesized by the following method:
[0054] Dissolve chitosan in a 1% acetic acid aqueous sol...
Embodiment 2
[0068] Dissolve doxorubicin in dimethyl sulfoxide, dissolve the glucose-modified amphiphilic chitosan derivative that is the drug delivery carrier in water, slowly add the doxorubicin solution to the drug delivery carrier solution under rapid stirring. After mixing the two solutions, ultrasonic 0.25h, ultrasonic power 250w, ultrasonic frequency 30KHz, deionized water dialysis, 0.22μm microporous filter membrane to filter out unencapsulated doxorubicin, that is, glucose-modified brain tumor targeting nanomicelle delivery Medicine system.
[0069] The concentration of the doxorubicin in dimethyl sulfoxide is 8 mg / mL; the concentration of the drug delivery vehicle in water is 20 mg / mL; the weight ratio of the doxorubicin to the drug delivery vehicle is 1:7;
[0070] The weight ratio of the drug to the drug delivery carrier in the prepared drug delivery system is 1:8;
[0071] The drug delivery carrier is synthesized by the following method:
Embodiment 3
[0086] Dissolve gambogic acid in dichloromethane, dissolve the glucose-modified amphiphilic chitosan derivative, which is the drug delivery carrier, in water, and slowly add the gambogic acid solution to the drug delivery carrier solution under rapid stirring. After the solution is mixed, ultrasonic for 0.3h, ultrasonic power 400w, ultrasonic frequency 25KHz, deionized water dialysis, 0.22μm microporous filter membrane to filter out unencapsulated gambogic acid, then glucose-modified brain tumor targeting nanomicelle delivery system.
[0087] The concentration of the gambogic acid in methylene chloride is 20 mg / mL; the concentration of the drug delivery vehicle in water is 35 mg / mL; the weight ratio of the gambogic acid to the drug delivery vehicle is 1:6;
[0088] The weight ratio of the drug to the drug delivery carrier in the prepared drug delivery system is 1:7;
[0089] The drug delivery carrier is synthesized by the following method:
[0090] Disperse chitosan in methanol, stir...
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