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Colloidal bismuth subcitrate composition freeze-dried tablet and preparation method thereof

A technology of potassium bismuth citrate and composition is applied in the field of freeze-dried tablets of potassium bismuth citrate composition and preparation thereof, and achieves the effects of good formability, improved dissolution and improved adhesion

Inactive Publication Date: 2015-05-06
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of bismuth potassium citrate freeze-dried tablets by freeze-drying process

Method used

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  • Colloidal bismuth subcitrate composition freeze-dried tablet and preparation method thereof
  • Colloidal bismuth subcitrate composition freeze-dried tablet and preparation method thereof
  • Colloidal bismuth subcitrate composition freeze-dried tablet and preparation method thereof

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Effect test

Embodiment 1

[0025]

[0026] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V ) of cornstarch solution.

[0027] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0028] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0029] D. Weigh 300 g of potassium bismuth citrate, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0030] E. After measuring the content of bismuth potass...

Embodiment 2

[0033]

[0034] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0035] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0036] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0037] D, take by weighing 300 grams of bismuth potassium citrate (calculated as 1000 tablets), add 1L corn-sucrose solution, and stir for 30 minutes.

[0038] E. After measuring the...

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Abstract

The invention provides a colloidal bismuth subcitrate composition freeze-dried tablet and a preparation method thereof, and relating to the technical field of medicines and medicine production. The colloidal bismuth subcitrate composition freeze-dried tablet comprises colloidal bismuth subcitrate, starch and saccharose, wherein the starch and the saccharose are used as auxiliary materials; common maize starch is subjected to a heating process, so that the adhesion and disaggregation effects of the starch in the tablet are enhanced, and the formability of the tablet is enhanced. The colloidal bismuth subcitrate composition freeze-dried tablet only needs two auxiliary materials, namely the starch and the saccharose. A double-reduction double-increase freeze-drying process is adopted for the colloidal bismuth subcitrate composition freeze-dried tablet, the preferable formability of the tablet can be achieved through two-time temperature reduction and two-time temperature increase, and the dissolubility of the tablet is enhanced, so that the bioavailability of the tablet is enhanced. The colloidal bismuth subcitrate composition freeze-dried tablet provided by the invention overcomes the defects of a common colloidal bismuth subcitrate tablet and reduces the variety and usage amount of the auxiliary materials of the colloidal bismuth subcitrate tablet, is high in dissolubility and high in bioavailability and ensures the treatment effect and safety of clinical medication.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of bismuth potassium citrate composition and a preparation method thereof. Background technique [0002] Potassium bismuth citrate is a bismuth-containing compound of variable composition. [0003] This product does not neutralize gastric acid, nor inhibit gastric acid secretion, but under the pH value of gastric juice, a solid bismuth oxide colloidal precipitation is formed on the ulcer surface or ulcer basal granulation tissue, which becomes a protective film, thereby isolating gastric acid, enzymes and The erosive effect of food on ulcer mucosa promotes the repair and healing of ulcer tissue. In vitro experiments have proved that this product can coagulate by complexing with proteins and amino acids under acidic conditions, and the amino acid residues at the ulcer site are much more abundant than normal mucosa, so this product is...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/194A61K47/36A61K47/26A61P1/04
Inventor 王丹石金友汪金灿郝结兵吴函峰
Owner HAINAN WEI KANG PHARMA QIANSHAN
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