Etoricoxib dispersible tablets and preparation method thereof

Abstract

The invention discloses etoricoxib dispersible tablets and a preparation method thereof. The etoricoxib dispersible tablets are prepared by the following steps: by adopting etoricoxib as an active pharmaceutical ingredient, dissolving the active pharmaceutical ingredient and carriers in a solvent, adopting a pressure reducing and drying or spraying and drying technology to prepare into solid dispersion bodies, and then using the solid dispersion bodies to prepare into the dispersible tablets. The etoricoxib dispersible tablets disclosed by the invention have the advantages that the etoricoxib and a proper amount of carriers are adopted to be prepared into the solid dispersion bodies, so that the solubility and the dissolving-out speed of medicines are increased, the absorption of the medicines in a body is enhanced, and the bioavailability of the medicines is improved; and simultaneously, the solid dispersion bodies are prepared into the dispersible tablets, so that the compliance of administration of a patient is enhanced.

Description

technical field

[0001] The invention relates to a pharmaceutical preparation in the category of oral rapid release, in particular to an etoricoxib dispersible tablet and a preparation method thereof. Background technique

[0002] Etoricoxib, chemical name is 5-chloro-6-methyl-3[4-(methylsulfonyl)phenyl]-2,3-bipyridine, molecular formula: C 18 h 15 CIN 2 o 2 S, molecular weight: 358.84, its structure is as follows:

[0003] .

[0004] Etoricoxib is a new type of highly selective COX-2 inhibitor, and its selective inhibitory effect on COX-2 is 100 times that of COX-1; in vitro studies have shown that etoricoxib has a strong selective effect on COX-2 than any other currently available COX-2 selective inhibitor. Etoricoxib has been approved for the treatment of osteoarthritis by more than 80 countries in Europe, Latin America, and Asia Pacific, and the recommended dose is 30 mg and 60 mg, once a day. A number of clinical studies have shown that the therapeutic effect of...