Micro-fluidic chip surface hydrophilic modification treatment method and hydrophilic surface gradient manufacture method

Abstract

The invention relates to the technical field of micro-fluidic chips, and discloses a micro-fluidic chip surface hydrophilic modification treatment method and a hydrophilic surface gradient manufacture method. The micro-fluidic chip surface hydrophilic modification treatment method comprises the following steps: (1), a hydrophilic solution is prepared; (2), a mask is produced according to a micro-channel pattern requiring for hydrophilic treatment; (3), the hydrophilic solution is injected into a pipeline of a micro-fluidic chip; (4), the upper surface of the micro-fluidic chip is covered with the mask; (5), the chip is placed in a UV (ultraviolet) light curing machine to be irradiated for gradient minutes; (6), the chip is taken out of the UV light curing machine and cooled; (7), a grafting solution in the micro-channel is sucked out with negative pressure, cleaned with distilled water, soaked, washed to remove homopolymer and dried in vacuum. The UV light is adopted for modification treatment of a local area of the micro-channel or for manufacturing hydrophilic gradient, and a manufactured hydrophilic film has the advantages of uniform film body, good hydrophilic characteristic, easiness in operation and the like.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a hydrophilic modification treatment on the surface of a microfluidic chip and a method for making a hydrophilic surface gradient. Background technique [0002] Microfluidic chips, also known as micro-total analysis systems, are a type of micro-reaction or analysis systems characterized by micro-channel networks. Due to the advantages of fast analysis speed, low reagent consumption, low cost of use, easy integration and automation, microfluidic chips have become a very active scientific frontier and have been widely used in research in chemistry, biology, medicine and other fields. . The materials used to make microfluidic chips mainly include glass, quartz, and high molecular polymers. Among them, high molecular polymer materials are cheap, easy to manufacture, and do not require expensive instruments, ultra-clean room environments, and cumbersome preparation process...

AI Technical Summary

Problems solved by technology

However, the immersion method can only treat the surface of the article or part as a whole, and cannot treat the local area; the coating method is difficult to operate on the micro-channel, the coating is uneven, the boundary is blurred, and the modification effect is poor.

Images