Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ezetimibe tablet

An ezetimibe and tablet technology, applied in the field of ezetimibe tablets, can solve the problems of being unsuitable for industrial production, expensive and the like, and achieve the effects of good stability, fast dissolution rate and simple process

Active Publication Date: 2015-06-03
SHANDONG NEWTIME PHARMA
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires the use of supercritical equipment, which is expensive and operated at high pressure, and is not suitable for industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ezetimibe tablet
  • Ezetimibe tablet
  • Ezetimibe tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020]

[0021] Preparation Process:

[0022] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with lactose, sodium carboxymethyl starch, stearic acid Magnesium is homogeneously mixed and compressed using the direct compression process.

Embodiment 2

[0024]

[0025] Preparation Process:

[0026] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose, crospovidone, Magnesium stearate is mixed evenly and compressed by direct compression process.

Embodiment 3

[0028]

[0029] Preparation Process:

[0030] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose, crospovidone, Magnesium stearate is mixed evenly and compressed by direct compression process.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of drugs and in particular relates to an ezetimibe tablet. The ezetimibe tablet comprises ezetimibe, hydroxypropyl cellulose, diethylene glycol monoethyl ether, fumed silica, filling agents, disintegrating agents and lubricating agents. The tablet is prepared by dissolving ezetimibe and hydroxypropyl cellulose in diethylene glycol monoethyl ether, adding fumed silica for adsorption, then mixing the materials with pharmaceutically acceptable auxiliary materials uniformly and pressing the mixture by adopting a direct tabletting process. Compared with the prior art, the ezetimibe tablet is high in drug dissolution speed and simple in process and dispenses with addition of surfactants and micronization treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ezetimibe tablet. Background technique [0002] Ezetimibe is a white crystalline powder, easily soluble in ethanol, methanol and acetone, but almost insoluble in water. The melting point of ezetimibe is about 163°C, and it is stable at room temperature. Ezetimibe is mainly used clinically for primary hypercholesterolemia. As an adjuvant therapy other than diet control, this product can be used alone or in combination with HMG-CoA reductase inhibitors such as statins to treat hypercholesterolemia. Lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), or as an adjunct to other lipid-lowering treatments (such as LDL-C apheresis), can also be used in other It is used to reduce TC and LDL-C levels in HoFH patients when lipid-lowering therapy is ineffective. [0003] Ezetimibe is insoluble in water. When the solid dosag...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/397A61K47/04A61K47/32A61K47/38A61P3/06
Inventor 刘家胜吴善霞
Owner SHANDONG NEWTIME PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com