Ezetimibe tablet

An ezetimibe and tablet technology, applied in the field of ezetimibe tablets, can solve the problems of being unsuitable for industrial production, expensive and the like, and achieve the effects of good stability, fast dissolution rate and simple process

Active Publication Date: 2015-06-03
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires the use of supercritical equipment, which is expensive

Method used

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  • Ezetimibe tablet
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020]

[0021] Preparation Process:

[0022] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with lactose, sodium carboxymethyl starch, stearic acid Magnesium is homogeneously mixed and compressed using the direct compression process.

Embodiment 2

[0024]

[0025] Preparation Process:

[0026] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose, crospovidone, Magnesium stearate is mixed evenly and compressed by direct compression process.

Embodiment 3

[0028]

[0029] Preparation Process:

[0030] Dissolve ezetimibe in diethylene glycol monoethyl ether, add povidone, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose, crospovidone, Magnesium stearate is mixed evenly and compressed by direct compression process.

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PUM

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Abstract

The invention belongs to the technical field of drugs and in particular relates to an ezetimibe tablet. The ezetimibe tablet comprises ezetimibe, hydroxypropyl cellulose, diethylene glycol monoethyl ether, fumed silica, filling agents, disintegrating agents and lubricating agents. The tablet is prepared by dissolving ezetimibe and hydroxypropyl cellulose in diethylene glycol monoethyl ether, adding fumed silica for adsorption, then mixing the materials with pharmaceutically acceptable auxiliary materials uniformly and pressing the mixture by adopting a direct tabletting process. Compared with the prior art, the ezetimibe tablet is high in drug dissolution speed and simple in process and dispenses with addition of surfactants and micronization treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ezetimibe tablet. Background technique [0002] Ezetimibe is a white crystalline powder, easily soluble in ethanol, methanol and acetone, but almost insoluble in water. The melting point of ezetimibe is about 163°C, and it is stable at room temperature. Ezetimibe is mainly used clinically for primary hypercholesterolemia. As an adjuvant therapy other than diet control, this product can be used alone or in combination with HMG-CoA reductase inhibitors such as statins to treat hypercholesterolemia. Lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), or as an adjunct to other lipid-lowering treatments (such as LDL-C apheresis), can also be used in other It is used to reduce TC and LDL-C levels in HoFH patients when lipid-lowering therapy is ineffective. [0003] Ezetimibe is insoluble in water. When the solid dosag...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/397A61K47/04A61K47/32A61K47/38A61P3/06
Inventor 刘家胜吴善霞
Owner SHANDONG NEWTIME PHARMA
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