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Preparation method of targeted rare earth upconversion Au-core nanoparticle

A rare earth up-conversion, gold core-shell technology, applied in the field of medicine, can solve the problems that heating equipment cannot achieve precise heating, limit further application of hyperthermia, shallow heat penetration depth, etc., achieve high photothermal conversion efficiency, and reduce the treatment process. The effect of long and short preparation cycle

Inactive Publication Date: 2015-06-24
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, compared with the three traditional treatment methods of surgery, radiotherapy and chemotherapy, most of the hyperthermia for tumors is still in an auxiliary and secondary position. The equipment cannot achieve precise heating; 2) These defects such as shallow heat penetration depth directly limit the further clinical application of hyperthermia

Method used

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  • Preparation method of targeted rare earth upconversion Au-core nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0047] 1. Synthesis of rare earth upconversion-gold core-shell nanoparticles (UCNAu):

[0048] (1) Take 40mg of ytterbium chloride, 10mg of yttrium chloride and 1mg of erbium chloride respectively, add the above three substances into four milliliters of water, and heat to boiling under magnetic stirring conditions until the rare earth salt solution becomes a white solid.

[0049] (2) After the water is evaporated to dryness, add 6 mL of oleic acid ligand solvent and 1 mL of octadecyl ligand solvent with a pipette to completely dissolve the white solid;

[0050] (3) Cool to 60°C, add 6mgNaOH, 5mg ammonium fluoride, and dissolve with 5ml of methanol; adjust the temperature to 150°C, use an oil pump to evacuate for 40min, and pass argon; quickly heat up to 270°C, and maintain the reaction for 3 hours; After the completion, acetone was added for centrifugal purification, and the product up-converted nanoparticles were vacuum-dried.

[0051] (4) Take 10 mg of upconverting nanopart...

Embodiment 2

[0061] 1. Synthesis of rare earth upconversion-gold core-shell nanoparticles (UCNAu):

[0062] (1) Take 10mg of ytterbium chloride, 60mg of yttrium chloride and 1mg of erbium chloride respectively, add the above three substances into four milliliters of water, and heat to boiling under magnetic stirring conditions until the rare earth salt solution becomes a white solid.

[0063] (2) After the water is evaporated to dryness, add 20 mL of oleic acid ligand solvent and 10 mL of octadecene ligand solvent with a pipette to dissolve the white solid;

[0064] (3) Cool to 40°C, add 20mgNaOH, 5mg ammonium fluoride, and dissolve with 5ml of methanol; adjust the temperature to 100°C, use an oil pump to evacuate for 10min, and pass argon; quickly heat up to 250°C, and maintain the reaction for 2 hours; After the completion, acetone was added for centrifugal purification, and the product up-converted nanoparticles were vacuum-dried.

[0065] (4) Take 5 mg of upconverting nanoparticles an...

Embodiment 3

[0075] 1. Synthesis of rare earth upconversion-gold core-shell nanoparticles (UCNAu):

[0076] (1) Take 20mg of ytterbium chloride, 40mg of yttrium chloride and 1mg of erbium chloride respectively, add the above three substances into four milliliters of water, and heat to boiling under magnetic stirring conditions until the rare earth salt solution becomes a white solid.

[0077] (2) After the water is evaporated to dryness, add 20 mL of oleic acid ligand solvent and 5 mL of octadecyl ligand solvent with a pipette to completely dissolve the white solid;

[0078] (3) Cool to 60°C, add 1mgNaOH, 5mg ammonium fluoride, and dissolve with 5ml of methanol; adjust the temperature to 150°C, use an oil pump to evacuate for 30min, and pass argon; quickly heat up to 300°C, and maintain the reaction for 1 hour; After the end, acetone was added for centrifugal purification, and the product was vacuum-up-converted and dried with nanoparticles.

[0079] (4) Take 5 mg of upconverting nanopart...

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Abstract

The invention relates to a preparation method of a targeted rare earth upconversion Au-core nanoparticle. The preparation method of the targeted rare earth upconversion Au-core nanoparticle concretely comprises the following two steps: 1) synthesizing a rare earth upconversion Au-core nanoparticle; and 2) compounding the rare earth upconversion Au-core nanoparticle with mercaptoacetic acid and a targeting molecule RGD polypeptide, so that the targeted rare earth upconversion Au-core nanoparticle is obtained. Compared with the traditional tumour thermotherapy, the targeted rare earth upconversion Au-core nanoparticle has multiple advantages when used for carrying out tumour thermotherapy, large amount of heat can be produced under the condition of short irradiation, so that the defect of long therapeutic process during the traditional therapy is overcome; meanwhile, the targeted rare earth upconversion Au-core nanoparticle obtained through assembling has the advantages of stable structure, uniform particle size and high photothermal conversion efficiency.

Description

technical field [0001] The invention relates to a method for preparing targeted rare earth up-conversion gold core-shell nanoparticles, which belongs to the technical field of medicine. Background technique [0002] Tumors, especially malignant tumors, are one of the most important killers that threaten human health and even life. Currently, the commonly used clinical treatment methods include surgical resection, radiotherapy, and chemotherapy. However, the above methods also have certain defects, such as surgical resection will cause limb damage, radiotherapy and chemotherapy will cause damage to normal tissues due to side effects, all of which will inevitably reduce the survival rate and quality of life of patients. Clinically, we have been looking for a minimally invasive or even non-invasive treatment method that can effectively kill tumor cells while ensuring less damage and less toxic side effects. Modern tumor hyperthermia technology is a new solution with the above...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
Inventor 王汉杰张莹常津宫晓群郑斌王生
Owner TIANJIN UNIV
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