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Application of prepared fleeceflower root in preparation of anti-ultraviolet product and anti-aging externally-applied product

A technology for making Polygonum multiflorum and anti-ultraviolet rays, which is applied in the field of medicine, can solve the problems of anti-ultraviolet effect of Polygonum multiflorum and liver damage, etc., and achieve the effect of inhibiting the decline of SOD content, alleviating the decline, and improving self-healing ability

Inactive Publication Date: 2015-07-08
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Radix Polygoni Multiflori is a Lingnan medicinal material with a unique taste. Its oral pharmacological effects mainly include regulating immune function, lowering blood lipids, anti-atherosclerosis, myocardial protection, nerve protection, and antibacterial effects. However, long-term oral administration may can cause liver damage
Polygonum multiflorum in the prior art is mainly used for anti-aging, blood lipid lowering, anti-atherosclerosis and antibacterial effects. There is no research on whether Polygonum multiflorum has anti-ultraviolet effect. This patent studies the anti-ultraviolet effect of Polygonum multiflorum and tries to find a A kind of use method that reduces Radix Polygoni Multiflori to liver injury

Method used

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  • Application of prepared fleeceflower root in preparation of anti-ultraviolet product and anti-aging externally-applied product
  • Application of prepared fleeceflower root in preparation of anti-ultraviolet product and anti-aging externally-applied product
  • Application of prepared fleeceflower root in preparation of anti-ultraviolet product and anti-aging externally-applied product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of Radix Polygoni Multiflori Alcoholic Extract

[0030] Use the dried tuber root of Polygonum multiflorum Polygonum (Polygonum multiflorum) as raw material, after washing, drying, and pulverizing into coarse powder, use 70% ethanol-water as solvent, the ratio is (W / V=1:10), and reflux extraction 3 times, 2 h / time, combined alcohol extracts, concentrated under reduced pressure and dried to obtain dry powder for future use.

Embodiment 2

[0031] Example 2 Animal experiment of anti-ultraviolet radiation repair

[0032] 40 SPF grade KM mice were randomly divided into blank control group, cream base group, Polygonum multiflorum alcohol extract group and positive control group according to body weight. The backs of the mice were shaved 24 hours before the experiment. Each experimental group according to 2mg / cm 2 Apply the corresponding drug evenly, and irradiate under ultraviolet light after 25 minutes. The initial irradiation time was 30 minutes, and gradually increased every day until it stopped increasing after 1 hour, and the irradiation time was 14 days. After 14 days, the animals were sacrificed, and the activities of SOD and MDA in the skin homogenate were measured, and skin tissues were taken from each group for routine HE staining. Observe the structure of the epidermis and dermis, the thickness and distribution of collagen fibers under a microscope.

[0033] Among them, the blank control group di...

Embodiment 3

[0034] Example 3 Animal Anti-aging Experiment of Preparation of Polygonum Polygoni Multiflori Alcoholic Extract

[0035] 40 SPF grade KM mice were randomly divided into blank control group (A), cream base group (B), Polygonum multiflorum alcohol extract group (C) and positive control group (D) according to body weight. The backs of the mice in each group were shaved 2 cm×3 cm. Except the blank group, other groups were subcutaneously injected with 5% D-galactose 200mg·kg on the back of the neck every day -1 , a total of 28 days, the mouse subacute aging model was established; the blank group was not modeled. From the first day of modeling, the positive control group administered 3.0 mg / 10 g body weight to the mice at 9:00 every day, and the other groups received 2 mg·cm -2Apply the medicine every day for 8 consecutive days. Among them, the blank control group did not give the mice drugs; the cream base group used blank cream; the Polygonum multiflorum alcohol extract group ...

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Abstract

The invention relates to application of a prepared fleeceflower root extract in preparation of an anti-ultraviolet product. The anti-ultraviolet product is any pharmaceutically acceptable medicine prepared by taking the prepared fleeceflower root extract as an active component, wherein the anti-ultraviolet product is an externally-applied medicine. The invention also provides application of the prepared fleeceflower root extract in preparation of an anti-aging externally-applied product. The prepared fleeceflower root extract is capable of effectively inhibiting reduction of the content of SOD in body caused by the ultraviolet rays, inhibiting the increase of the content of MDA in the body caused by the ultraviolet rays, avoiding the physical damage of ultraviolet rays to the skin, improving the self-repairing capability of the skin and solving the problem of damage of ultraviolet radiation to the skin. When the prepared fleeceflower root extract is prepared into an externally-applied product, the prepared fleeceflower root extract is capable of simultaneously resisting ageing and remarkably reducing the damage of the prepared fleeceflower root extract to the liver; application methods of the prepared fleeceflower root are expanded; meanwhile, the safety of medicine administration is ensured.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of Polygonum multiflorum in preparing anti-ultraviolet products and anti-aging external products. Background technique [0002] The harm of ultraviolet rays to human health mainly comes from natural sunlight and artificial light used for medical treatment. Ultraviolet radiation from sunlight is an environmental carcinogen for humans. The acute diseases caused by ultraviolet radiation to the skin of ordinary people mainly include erythema, black spot and local or whole immune system function decline. [0003] At present, the methods used to prevent ultraviolet rays mainly include physical methods and chemical methods; physical methods mainly make ultraviolet rays refract, reflect, and scatter. The cream contains titanium dioxide, which is a very effective ultraviolet sunscreen and is harmless to the human body. Its disadvantage is that the physical sunscreen has a serious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P17/16A61P17/18
Inventor 王晖刘文彬薛漫清胡旭光
Owner GUANGDONG PHARMA UNIV
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