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Hyaluronic acid elastomer and applications thereof

A technology of hyaluronic acid and cross-linked hyaluronic acid, which is applied in the direction of dressing preparations, cosmetics, skin care preparations, etc., can solve problems such as blurred wrinkles, and achieve improved use feeling, excellent biocompatibility, and cross-linking The effect of low dosage

Active Publication Date: 2015-07-15
SHANDONG BLOOMAGE HYINC BIOPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent proposes the concept of using a gel system with particles to blur wrinkles. The gel is suitable for cosmetics, but the gel in the patent is made of silica, alumina, silicone elastomer and other materials, which are not biocompatible. hyaluronic acid gel

Method used

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  • Hyaluronic acid elastomer and applications thereof
  • Hyaluronic acid elastomer and applications thereof
  • Hyaluronic acid elastomer and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The impact of the particle size difference of the gel B investigated in this embodiment on the properties of the gel of the invention, the preparation method is as follows:

[0035] (1) Dissolve 10 g of hyaluronic acid in 100 ml of NaOH solution (pH value 11-13), mix well, add cross-linking agent 1,4-butanediol diglycidyl ether, cross-linking agent and The mass proportion of hyaluronic acid was 1%, stirred and mixed, and reacted in a water bath at 35°C for 6 hours to obtain cross-linked sodium hyaluronate gel A;

[0036] (2) Granulate cross-linked sodium hyaluronate gel A, the particle size of gel B is shown in Table 1, and the particle size of gel C is 72 μm (X 50 );

[0037] (3) Mix gel B and gel C at 1 : 1 (w : w), adjust the pH value to 2~4, add 1,4-butanediol diglycidyl ether, cross-linking agent and hyaluronic acid The mass proportion of 0.8% was reacted in a 30°C water bath for 8 h. Adjust the pH value to neutral, and dialyze to remove unreacted small molecula...

Embodiment 2

[0045] The impact of the particle size difference of the gel C investigated in this embodiment on the properties of the gel of the invention, the preparation method is as follows:

[0046](1) Dissolve 10 g of hyaluronic acid in 100 ml of NaOH solution (pH 11-13), mix well, add cross-linking agent 1,4-butanediol diglycidyl ether, cross-linking agent The mass ratio of hyaluronic acid and hyaluronic acid was 1.0%, stirred and mixed, and reacted in a water bath at 35°C for 6 hours to obtain cross-linked sodium hyaluronate gel A;

[0047] (2) Granulate cross-linked sodium hyaluronate gel A, and the particle size of gel B is 198 μm (X 50 ), the particle size of gel C is shown in Table 2;

[0048] (3) Mix gel B and gel C at 1 : 1 (w : w), adjust the pH value to 2~4, add 1,4-butanediol diglycidyl ether, cross-linking agent and hyaluronic acid The mass proportion of 0.8% was reacted in a 30°C water bath for 8 h. Adjust the pH value to neutral, and dialyze to remove unreacted small m...

example 1

[0049] The viscoelasticity and enzyme resistance of the gel were measured with reference to the method of Example 1, and the data are shown in Table 2.

[0050] Table 2 The effect of gel C with different particle sizes

[0051]

[0052] Gel C is selected with suitable viscoelasticity and moderate degradation rate. When the particles of Gel C are smaller than 60 μm, the resulting gel is more elastic and difficult to apply, so the particle size of Gel C (X 50 ) to choose 70~100 μm.

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Abstract

The invention relates to the technical field of sodium hyaluronate gel, and especially relates to a hyaluronic acid elastomer. The hyaluronic acid elastomer is prepared by the following steps: reacting hyaluronic acid with a crosslinking agent to obtain crosslinked sodium hyaluronate gel (A); granulating the obtained crosslinked sodium hyaluronate gel (A) to obtain gel (B) and gel (C) with different particle sizes; mixing the gel (B) and gel (C) to carry out crosslinking reactions again, adjusting the pH value to a neutral area, and carrying out dialysis to obtain the hyaluronic acid elastomer. The provided hyaluronic acid elastomer has an excellent rheology performance, can be used as a cosmetic raw material, can be used to eliminate skin wrinkles physically, maintain the skin water, slowly release the effective component, and improve the feeling. The invention further discloses applications of the hyaluronic acid elastomer.

Description

technical field [0001] The invention relates to a hyaluronic acid elastomer. The present invention has excellent viscoelasticity, and can be used as a raw material of cosmetics for physically smoothing wrinkles, maintaining skin moisture, slow-releasing functional ingredients, improving the feeling of use, and the like. Meanwhile, the present invention also relates to its application. Background technique [0002] Hyaluronic acid (HA) is a linear polymer mucopolysaccharide composed of repeating disaccharide units of glucuronic acid and acetylglucosamine. Hyaluronic acid is an endogenous substance in the human body and has good biocompatibility; it has high viscoelasticity and non-Newtonian rheological properties; it is non-toxic, non-immunogenic, non-irritating, and has a high safety. [0003] Non-cross-linked hyaluronic acid gel is widely used in cosmetics, but it is mainly used for moisturizing, and the amount added is very small, otherwise the solution will be v...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00A61Q19/08
Inventor 郭学平张燕刘建建杨莹莹
Owner SHANDONG BLOOMAGE HYINC BIOPHARM CORP LTD
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