Compound terbinafine preparation and applications thereof

A terbinafine and preparation technology, applied in the field of medicine, can solve problems such as abnormal pigmentation, skin flushing, etc., and achieve the effects of obvious clinical symptoms, improvement of clinical symptoms, and reduction of adverse hormone reactions

Inactive Publication Date: 2015-07-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of this type of hormone will cause side effects such as skin flushing, telangiectasia, acne (acne or acne), abnormal pigmentation, skin atrophy and thinning, swelling lines, skin purpura, hirsutism, and suppression of hormone secretion

Method used

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  • Compound terbinafine preparation and applications thereof
  • Compound terbinafine preparation and applications thereof
  • Compound terbinafine preparation and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the preparation of compound recipe terbinafine cream

[0027] The composition of each 1000g ointment is as follows:

[0028]

[0029] Heat and melt white vaseline, stearic acid, stearyl alcohol, liquid paraffin, and sorbitol, stir well, and keep warm at about 80°C to form the oil phase; take glycerin, Tween-80 Span-80 dimethyl sulfoxide, furoic acid Heat mometasone and terbinafine hydrochloride to melt in distilled water, stir well, and keep warm at about 80°C to form the water phase; slowly add the oil phase to the water phase while it is hot, stir well until it coagulates, and the product is obtained.

Embodiment 2

[0030] Embodiment 2: Clinical curative effect experiment of compound terbinafine emulsifiable cream of the present invention

[0031] 1. Treatment of tinea pedis and tinea pedis

[0032] From 2009 to 2013, we randomly selected 180 patients from the dermatology clinic of Changzheng Hospital who met the inclusion and exclusion criteria.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and provides a compound terbinafine preparation. The active component of the preparation is mainly composed of terbinafine hydrochloride and mometasone furoate. The provided compound terbinafine preparation is suitable for treating superficial fungal infection, and has the advantages of high curative effect, quick effect, safety, and little side effect of hormone. In the treatments of tinea of feet and hands, the clinical cure rate is 71.7%, the total effective rate is 96.7%, and the fungi eliminating rate is 100%. In the treatments of tinea corporis and cruris, the clinical cure rate is 72.4%, the total effective rate is 97.1%, and the fungus eliminating rate is 100%. The preparation does not cause prominent allergic reactions and hormone side effects.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a compound terbinafine preparation and its application in the preparation of medicines for treating superficial fungal infections. Background technique [0002] Fungal infection can be divided into superficial infection and deep infection, and superficial fungal infection is the most common in clinical skin diseases. Superficial mycoses involve infections of the epidermis, hair, and nails and are caused by Microsporum, Trichophyton, Candida, and Malassezia infections. Can cause tinea capitis (including tinea jaundice, white tinea, black spot tinea, pyogenic tinea), tinea corporis, jock itch, tinea pedis, tinea manuum, tinea unguium, tinea versicolor, etc. Although superficial mycosis is not fatal, its clinical manifestations are relatively stubborn, its incidence is high, and it is transmissible to a certain extent. It is a health problem that plagues the daily lif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/06A61P31/10A61K31/137
Inventor 廖万清潘炜华方文捷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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