Florfenicol included controlled-release preparation and its preparing method and application

A technology of florfenicol and controlled-release preparations, applied in the field of medicine, can solve problems such as poor clinical effects, achieve excellent sustained-release performance, prevent burst release, and improve bioavailability

Active Publication Date: 2015-08-12
CHINANIMAL NANJING VETERINARY DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved in the present invention is to provide a florfenicol inclusion controlled-release preparation to solve the problem of poor clinical effect of existing florfenicol products

Method used

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  • Florfenicol included controlled-release preparation and its preparing method and application
  • Florfenicol included controlled-release preparation and its preparing method and application
  • Florfenicol included controlled-release preparation and its preparing method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation of the florfenicol inclusion controlled-release preparation provided in this example is as follows:

[0051]

[0052] The specific preparation method is as follows:

[0053] (1) Take an appropriate amount of purified water and heat it to 80°C, add β-cyclodextrin and stir to dissolve, then add Florfenicol and stir for 30 minutes to form a Florfenicol inclusion solution;

[0054] (2) Adjust the spray dryer inlet air temperature to 160°C, the air outlet temperature to 80°C, and the pressure to 0.3MPa, and spray-dry the above-mentioned florfenicol inclusion solution to obtain the florfenicol soluble powder;

[0055](3) Take 66.25g of the above-mentioned Florfenicol soluble powder, microcrystalline cellulose, and sodium carboxymethylcellulose and mix them, add 26.47g of water, and mix them to make a soft material;

[0056] (4) Adjust the extrusion frequency of the extrusion spheronizer to 25 Hz, the spheronization frequency to 30 Hz, and the spheronizatio...

Embodiment 2

[0059] The preparation of the florfenicol inclusion controlled-release preparation provided in this example is as follows:

[0060]

[0061] The specific preparation method is as follows:

[0062] (1) Take an appropriate amount of purified water and heat it to 80°C, add β-cyclodextrin and stir to dissolve, then add Florfenicol and stir for 30 minutes to form a Florfenicol inclusion solution;

[0063] (2) Adjust the spray dryer inlet air temperature to 160°C, the air outlet temperature to 80°C, and the pressure to 0.3MPa, and spray-dry the above-mentioned florfenicol inclusion solution to obtain the florfenicol soluble powder;

[0064] (3) Take 66.25g of the above-mentioned Florfenicol soluble powder, microcrystalline cellulose, and sodium carboxymethylcellulose and mix them, add 26.47g of water, and mix them to make a soft material;

[0065] (4) Adjust the extrusion frequency of the extrusion spheronizer to 25 Hz, the spheronization frequency to 30 Hz, and the spheronizati...

Embodiment 3

[0068] The preparation of the florfenicol inclusion controlled-release preparation provided in this example is as follows:

[0069]

[0070] The specific preparation method is as follows:

[0071] (1) Take an appropriate amount of purified water and heat it to 80°C, add β-cyclodextrin and stir to dissolve, then add Florfenicol and stir for 30 minutes to form a Florfenicol inclusion solution;

[0072] (2) Adjust the spray dryer inlet air temperature to 160°C, the air outlet temperature to 80°C, and the pressure to 0.3MPa, and spray-dry the above-mentioned florfenicol inclusion solution to obtain the florfenicol soluble powder;

[0073] (3) Take 66.44g of the above-mentioned florfenicol soluble powder, microcrystalline cellulose, sodium carboxymethyl cellulose and mix, add 24.92g of water, and mix to make a soft material;

[0074] (4) Adjust the extrusion frequency of the extrusion spheronizer to 25 Hz, the spheronization frequency to 30 Hz, and the spheronization time to 4 ...

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PUM

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Abstract

The invention discloses florfenicol included controlled-release granules, prepared by developing an inner core made by florfenicol inclusion, with a controlled-release film. The invention further discloses a method of preparing the florfenicol included controlled-release granules and its application in the preparation of veterinary antibiotics. Compared with the prior art, the florfenicol included controlled-release granules has the advantages that solubility of florfenicol and bioavailability thereof are effectively improved, the granules can release fast in the early stage of administering to minimum antibiotic concentration, resulting in efficacy and can release slowly later, the efficacy is kept long, and no toxic or side effects occur; meanwhile, the materials for use in the preparing method are safe and easy to obtain, and the preparing method is suitable for wider range of production.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a florfenicol inclusion controlled-release preparation and a preparation method and application thereof. Background technique [0002] Florfenicol is a new type of broad-spectrum chloramphenicol antibiotic for animals. In the 1970s, it was developed by Schering-Plough in the United States. In the 1990s, it was approved by the FDA for bovine respiratory diseases. Florfenicol has a wide antibacterial spectrum and can act on a variety of bacteria, mycoplasma, chlamydia, etc.; it is widely distributed in the body, and will not produce adverse reactions of aplastic anemia caused by traditional chloramphenicol antibiotics, and has high safety. It has been used in the prevention and treatment of various animal (such as aquatic products, poultry, livestock) diseases in more than 20 countries. [0003] The two basic factors for antibacterial drugs to achieve curative effect on bacter...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/165A61K47/48A61K47/38A61P31/04
Inventor 徐瑞华马小平戴银娣胡娟徐学梅
Owner CHINANIMAL NANJING VETERINARY DRUGS
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