Preparation method of gold-graphene composite nanomaterial, and application of composite nanomaterial in glucose detection

A graphene composite and nanomaterial technology, applied in the direction of material electrochemical variables, etc., can solve the problems of nanomaterials that are difficult to control product distribution, morphology and particle size, easy to fall off during storage and use, and poor catalyst adhesion. Effects of catalytic activity and stability, wide detection limit, and structural stability

Inactive Publication Date: 2015-08-12
HUBEI UNIV
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Problems solved by technology

However, it is difficult to control the distribution, morphology and particle size of the nanomaterials prepared by the chemical reduction method; moreover, the prepared catalysts have poor adhesion on electrodes or devices, are easy to fall off during storage and use, and have unstable stability. it is good

Method used

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  • Preparation method of gold-graphene composite nanomaterial, and application of composite nanomaterial in glucose detection
  • Preparation method of gold-graphene composite nanomaterial, and application of composite nanomaterial in glucose detection
  • Preparation method of gold-graphene composite nanomaterial, and application of composite nanomaterial in glucose detection

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[0016] The present invention provides a kind of preparation method of gold-graphene composite nano material on the one hand, it comprises the following steps:

[0017] A. Prepare the soluble salt solution of gold, add graphene oxide, and disperse evenly;

[0018] B. Insert the positive electrode and the negative electrode, pass direct current, constant voltage, and obtain the deposited gold-graphene composite nanomaterial on the surface of the negative electrode.

[0019] As an improvement to the present invention, the soluble gold salt solution is tetrachloroauric acid or potassium tetrachloroaurate.

[0020] As an improvement to the present invention, the graphene oxide is secondary graphene oxide. Concrete, the preparation process of described secondary graphene oxide comprises:

[0021] A1. Pre-oxidation: mix concentrated sulfuric acid, K 2 S 2 o 8 ,P 2 o 5 and graphite at 85°C for 8 hours, diluted with water, filtered and washed until the pH of the filtrate was neu...

Embodiment 1

[0034] First, prepare secondary graphene oxide:

[0035] 1. Pre-oxidation: Add 10mL concentrated sulfuric acid and 1g K 2 S 2 o 8 , 1g P 2 o 5 and 1g of graphite powder and stirred vigorously at 85°C for 8 hours, then transferred the reactant to a large beaker, diluted with water, filtered and washed until the filtrate was neutral, and dried in vacuum at 60°C to obtain pre-oxidized graphite.

[0036] 2. Secondary oxidation: add 11.5mL concentrated sulfuric acid to the reagent bottle and bathe in ice for 10 minutes, then add 0.5g pre-oxidized graphite, KMnO 4 1.5g, stirred and reacted for 1 hour in an ice bath; heated to 35°C, reacted for 2 hours; transferred the reactant to a 100mL beaker, added 23mL ultrapure water to continue the reaction for 10 minutes, added 70mL ultrapure water and stirred evenly, then added 1.5 mL 30% H 2 o 2 , stir (the solution turns bright yellow); wash with 500mL 10% HCl suction filtration until the filtrate is neutral; disperse the product ob...

Embodiment 2

[0043] This embodiment is basically the same as Embodiment 1, except that during the preparation of the gold-graphene nanocomposite material, the deposition time is 1 minute by direct current power supply.

[0044] The morphology of the gold-graphene nanocomposite material prepared by the final test, such as figure 2 shown. Through the electrochemical test, the current density of the composite material catalyzing glucose under the detection voltage of 0V vs. (Ag / AgCl) is 46μA / cm 2 ,like Figure 4 shown.

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Abstract

The invention provides a preparation method of a gold-graphene composite nanomaterial, and an application of the gold-graphene composite nanomaterial in glucose detection. The preparation method has the advantages of simplicity, fastness and good repeatability; the above obtained gold-graphene nanocatalyst can be firmly adhered to the surface of an electrode; gold nanoparticles are uniformly dispersed in a graphene flake, and the highly dispersed gold particles provide a large surface area for an electric cataltyic reaction, so the detection sensitivity is improved; and graphene can promote the electron transfer rate due to high electric conductivity, and can effectively prevent the agglomeration phenomenon in the detection process due to stable layered structure in order to improve the catalysis property and the stability. The gold-graphene composite nanomaterial has the advantages of high sensitivity and wide detection limit in the glucose detection, and allows the response time to glucose to be shorter than 3s and the lowest detection limit to be 25[mu]moL/L during electrochemical test.

Description

technical field [0001] The invention relates to an enzyme-free glucose detection catalyst, in particular to a preparation method and application of a gold-graphene composite nanomaterial. Background technique [0002] Accurate detection of glucose is crucial for the diagnosis and treatment of diabetes, and the development of glucose sensors has always been the focus of the development of the sensor field. However, the enzyme glucose electrochemical sensor is the most researched at present, because the inherent instability of the enzyme affects the long-term and accuracy of its application. Therefore, how to develop a stable, efficient and economical enzyme-free glucose electrochemical sensor is an urgent problem to be solved in the development of glucose sensors. [0003] The gold-graphene composite greatly reduces the amount of precious metal gold used, and enhances the activity and stability of the catalyst. Currently, the reported methods for preparing gold-graphene com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 常钢舒宏晖何云斌苏界贾红梅
Owner HUBEI UNIV
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