Resin with specific adsorption for cephalosporin C and preparation method therefor

A specific and spore-forming technology, which is applied in the field of resin with specific adsorption to cephalosporin C and its preparation, can solve the problem that the adsorption amount and selectivity cannot be balanced, and achieve strong anti-pollution ability and high selectivity performance , the effect of stable performance

Active Publication Date: 2015-08-19
AMICOGEN CHINA BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a kind of resin that can specifically adsorb cephalosporin C in order to overcome the deficiency that existing adsorption resins cannot take into account the adsorption capacity and selectivity. The adsorption head C copolymer is prepared by selecting an ideal porogenic system, and then adopts Aromatic alkylating agent is used for Friedel-Crafts alkylation of the copolymer, thereby increasing the density of benzene rings without changing the pore size, and the adsorbent has specific adsorption for cephalosporin C

Method used

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  • Resin with specific adsorption for cephalosporin C and preparation method therefor
  • Resin with specific adsorption for cephalosporin C and preparation method therefor
  • Resin with specific adsorption for cephalosporin C and preparation method therefor

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The monomer mixture that will contain 100g (80% content) divinylbenzene, 100g toluene and 50g sec-butyl acetate and 1.0g benzoyl peroxide is added in the dispersion medium solution that is made up of 500ml anhydrous salt water, 5g gelatin, stirs Make uniform droplets of a certain size, raise the temperature to 80°C, and react for 12 hours. Then drain the water, add water again, heat up to 50-60°C, stir and wash three times, add 500ml of water and heat up to azeotropic distillation to remove the porogen (toluene and sec-butyl acetate), until the condensate is almost free of oil material, stop distillation. After cooling down to room temperature, wash the spheres with a large amount of water, drain the water, then dry with hot air until the water content is below 1.0%, and sieve the spheres with 30-60 mesh to obtain 95 g of cross-linked macroporous copolymer matrix.

[0036] Add 95g of the cross-linked macroporous copolymer matrix obtained above into 450ml of nitrobenzen...

Embodiment 2

[0038] The monomer mixture that will contain 100g (80% content) divinylbenzene, 90g toluene and 150g methyl isobutyl carbinol and 1.0g benzoyl peroxide is added in the dispersion medium solution that is made up of 500ml anhydrous salt water, 5g gelatin , stirred to form uniform droplets of a certain size, heated to 75°C, and reacted for 12 hours. Then drain the water,. Then drain the water, re-add water, heat up to 50-60°C, stir and wash three times, add 500ml of water and heat up to azeotropic distillation to remove porogens (toluene and methyl isobutyl carbinol), until almost no Contains oil, stop distillation. Cool down, wash the spheres with a large amount of water, drain the water, then dry with hot air until the water content is below 1.0%, and sieve the spheres with 30-60 mesh to obtain 90 g of cross-linked macroporous copolymer matrix.

[0039] Add 90g of the cross-linked macroporous copolymer matrix obtained above into 570ml of dichloroethane, stir and swell at room...

Embodiment 3

[0041] The monomer mixture that will contain 100g (80% content) divinylbenzene, 150g toluene and 70g methyl isobutyl ketone and 1.0g benzoyl peroxide is added in the dispersion medium solution that is made up of 500ml anhydrous salt water, 5g gelatin, Stir to form uniform droplets of a certain size, raise the temperature to 75°C, and react for 12 hours. . Then drain the water, re-add water, heat up to 50-60°C, stir and wash three times, add 500ml of water and heat up to azeotropic distillation to remove porogens (toluene and methyl isobutyl carbinol), until almost no Contains oil, stop distillation. Cool down, wash the spheres with a large amount of water, drain the water, then dry with hot air until the water content is below 1.0%, and sieve the spheres with 30-60 mesh to obtain 85 g of cross-linked macroporous copolymer matrix.

[0042] The 85g cross-linked macroporous copolymer matrix obtained above was added in 510ml ethylene dichloride, stirred and swelled at room tempe...

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Abstract

The invention discloses resin with specific adsorption for cephalosporin C and a preparation method therefor. The adsorption resin is prepared by adopting suspension polymerization. The preparation method comprises the steps of: after mixing a monomer, a cross-linking agent, a pore-foaming agent, an initiator and water, performing a suspension polymerization reaction under the condition of the existence of a conventional dispersing agent, wherein the suspension polymerization temperature is 75 to 85 DEG C and the polymerization reaction time is 10 to 16 hours; carrying out distillation and drying treatment on the obtained polymer; adding the dried polymer and an inert solvent into a reactor together for swelling, adding lewis acid at room temperature, dropwise adding an alkylation reagent, heating to 40 to 50 DEG C to perform a friedel-crafts alkylation reaction for 12 to 16 hours, and carrying out solvent washing and washing to obtain the cephalosporin C specific adsorption resin. The cephalosporin C specific adsorption resin prepared by the method has specific adsorption for cephalosporin C, and is large in adsorption quantity and high in purity.

Description

technical field [0001] The invention relates to a novel functional polymer adsorbent, in particular to a resin capable of specifically adsorbing cephalosporin C and a preparation method thereof. Background technique [0002] The output of cephalosporins accounts for more than 60% of the world's antibiotic output, while the output of cephalosporin C in my country accounts for more than 80% of the world's total output. It is generally produced by fermentation, and the extraction of cephalosporin C fermented liquid uses the resin method. The extraction of cephalosporin C by macroporous adsorption resin has the characteristics of simple operation, no pollution to the product, low production cost and high yield. However, the existing macroporous adsorption resins also have the contradiction that the adsorption capacity and selectivity cannot be balanced. The adsorption of cephalosporin C by the macroporous adsorption resin is mainly due to the π-π effect formed by the benzene ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F112/36C08F8/02C08J9/28B01J20/26B01D15/08
Inventor 高博罗文军李建国杨申永王玲
Owner AMICOGEN CHINA BIOPHARM CO LTD
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