Venlafaxine hydrochloride sustained-release capsule and preparation method thereof
A technology of venlafaxine hydrochloride and sustained-release capsules, which is applied in the field of medicine, can solve the problems of high solution viscosity and low drug yield, and achieve the effects of simple preparation process, consistent sustained-release curve, and cost-saving production
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[0035] Example 1
[0036]
[0037] Preparation method: Weigh the prescription amount of venlafaxine hydrochloride and add it to a certain amount of ethanol, stir to dissolve to prepare a drug solution; then weigh the prescription amount of hypromellose into a quantitative amount of water, stir to dissolve, and then A prescription amount of talc powder is added to prepare a separation liquid; polyvinyl acetate-povidone is added to water to prepare a dispersion liquid, then triethyl citrate and talc powder are added, and the mixture is stirred to make the dispersion uniform. Using a sucrose pellet core as a substrate, use a fluidized bed to coat the drug solution, spacer solution, and coating solution on the surface of the pellet core until the coating solution is completely sprayed to obtain drug-containing sustained-release pellets. Fill into hard capsules.
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[0038] Example 2
[0039]
[0040] The preparation method is the same as in Example 1.
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[0041] Example 3
[0042]
[0043] The preparation method is the same as in Example 1.
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