Super-lubricant antibacterial catheter and preparation method thereof

The technology of a urinary catheter and an antibacterial layer is applied in the field of ultra-smooth antibacterial urinary catheter and its preparation, which can solve the problems of inconvenient movement of patients, inconvenience of patients, and difficulty in insertion, and achieve the effect of reducing drug resistance and adverse reactions

Inactive Publication Date: 2015-09-02
NANJING SKY LONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Clinically, urinary catheters are used for patients with voiding disorders caused by various reasons or specific operations, and patients who need to record urine volume per unit time. Although the existing urinary catheters are convenient and feasible, they also have the following problems: After use, in order to maintain sterility and liquid backflow, usually use a urine bag to close the mouth, which brings great inconvenience to the patient's activities; it is mostly made of natural rubber, silicone rubber or polyvinyl chloride (PVC), which is difficult for medical staff to insert during operation, which brings great inconvenience to the patient. inconvenient pain

Method used

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  • Super-lubricant antibacterial catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Such as figure 1 The shown ultra-slippery antibacterial catheter includes a catheter body 3 , the surface of the catheter body 3 is coated with an antibacterial layer 2 , and the surface of the antibacterial layer 2 is coated with a lubricating layer 1 . The catheter body 3 is made of silica gel.

[0019] The preparation method of above-mentioned ultra-smooth antibacterial catheter comprises the steps:

[0020] (1) Prepare the following raw materials according to mass percentage: 0.5% chitosan, 10% propylene glycol, 10% glycerin, 0.2% sodium benzoate, 0.5% citrate, 0.3% essence, and the balance is purified water; the above raw materials are made into Emulsion and adjust the pH value to 5;

[0021] (2) Submerge the catheter body in the step (1) to prepare the emulsion, and stay for 1 minute to form an antibacterial layer;

[0022] (3) Immerse the catheter body obtained in step (2) in the liquid with a concentration of 2% hydroxypropyl cellulose, and stay ...

Embodiment 2

[0025] Example 2: The preparation method of above-mentioned ultra-smooth antibacterial catheter comprises the steps:

[0026] (1) Prepare the following raw materials according to mass percentage: 1% chitosan, 20% propylene glycol, 20% glycerin, 1% sodium benzoate, 1% citric acid, 0.8% essence, and the balance is purified water; the above raw materials are made into Gel and adjust the pH value to 6;

[0027] (2) Spray the gel prepared in the step (1) on the surface of the catheter body, the spray is even and the thickness is 2mm;

[0028] (3) Immerse the catheter body obtained in step (2) in the liquid with a concentration of 2% hydroxypropyl cellulose, and stay for 1 minute to form a lubricating layer;

[0029] (4) Dry the film formed after combining the antibacterial layer and the lubricating layer, and the drying temperature is 40°C;

[0030] (5) Use 625 mg / L ethylene oxide to sterilize the urinary catheter body obtained in step (4), the sterilization temperature is 53°C...

Embodiment 3

[0031] Example 3: The preparation method of above-mentioned ultra-smooth antibacterial catheter comprises the steps:

[0032] (1) Prepare the following raw materials according to mass percentage: 2% chitosan, 10% propylene glycol, 10% glycerin, 2% sodium benzoate, 2% citric acid, 1.5% essence, and the balance is purified water; the above raw materials are made into Gel and adjust the pH value to 7;

[0033] (2) Spray 10ml of the gel prepared in step (1) evenly on the surface of a catheter body;

[0034] (3) Put the catheter body obtained in step (2) in 3% hypromellose liquid, and stay for 2 minutes to form an antibacterial layer;

[0035] (4) Dry the film formed by combining the antibacterial layer and the lubricating layer, and the drying temperature is 50°C;

[0036] (5) Use 8555mg / L ethylene oxide to sterilize the catheter body obtained in step (4), the sterilization temperature is 56°C, the pre-vacuum degree is -25kPa, the sterilization time is 30min, and the steriliza...

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Abstract

The invention discloses a super-lubricant antibacterial catheter and a preparation method thereof. The body of the catheter is orderly coated with a chitosan antibacterial layer and a hydroxypropylcellulose lubricating layer, and then dried and sterilized, and consequently, the super-lubricant antibacterial catheter can be obtained. The super-smooth antibacterial catheter is capable of achieving the effects of antibiosis and lubrication by use of the antibacterial capability of the chitosan and the lubrication capability of the hydroxypropylcellulose, wherein the chitosan serves as an antibacterial ingredient of biogenetic derivation, and is capable of reducing drug resistance and untoward effects caused by medical bacteriostatic agents to a user.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a super-smooth antibacterial urinary catheter and a preparation method thereof. Background technique [0002] Clinically, urinary catheters are used for patients with voiding disorders caused by various reasons or specific operations, and patients who need to record urine volume per unit time. Although the existing urinary catheters are convenient and feasible, they also have the following problems: After use, in order to maintain sterility and liquid backflow, usually use a urine bag to close the mouth, which brings great inconvenience to the patient's activities; it is mostly made of natural rubber, silicone rubber or polyvinyl chloride (PVC), which is difficult for medical staff to insert during operation, which brings great inconvenience to the patient. Inconvenient pain. Contents of the invention [0003] Purpose of the invention: Aiming at the deficiencies of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/16A61L29/14A61L29/04A61L29/06
Inventor 温天文黄波魏民刘世龙史翔
Owner NANJING SKY LONG PHARMA
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